Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Anti-Phospho-MAPK3/1 (Thr202/Tyr204) Polyclonal Antibody

😃Good
Catalog No. TMAC-01368

Anti-Phospho-MAPK3/1 (Thr202/Tyr204) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MAPK3/1 (Thr202/Tyr204). Anti-Phospho-MAPK3/1 (Thr202/Tyr204) Polyclonal Antibody can be used in WB,IHC,IF.

Anti-Phospho-MAPK3/1 (Thr202/Tyr204) Polyclonal Antibody

Anti-Phospho-MAPK3/1 (Thr202/Tyr204) Polyclonal Antibody

😃Good
Catalog No. TMAC-01368
Anti-Phospho-MAPK3/1 (Thr202/Tyr204) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MAPK3/1 (Thr202/Tyr204). Anti-Phospho-MAPK3/1 (Thr202/Tyr204) Polyclonal Antibody can be used in WB,IHC,IF.
Pack SizePriceAvailabilityQuantity
50 μL$2187-10 days
100 μL$3167-10 days
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View More

Product Introduction

Bioactivity
Description
Anti-Phospho-MAPK3/1 (Thr202/Tyr204) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MAPK3/1 (Thr202/Tyr204). Anti-Phospho-MAPK3/1 (Thr202/Tyr204) Polyclonal Antibody can be used in WB,IHC,IF.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundSerine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of Threonine 202/Tyrosine 204(F-L-T(p)-E-Y(p)-V-A)Sderived from Human ERK1/2
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 42, 44 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy Anti-Phospho-MAPK3/1 (Thr202/Tyr204) Polyclonal Antibody | purchase Anti-Phospho-MAPK3/1 (Thr202/Tyr204) Polyclonal Antibody | Anti-Phospho-MAPK3/1 (Thr202/Tyr204) Polyclonal Antibody cost | order Anti-Phospho-MAPK3/1 (Thr202/Tyr204) Polyclonal Antibody | Anti-Phospho-MAPK3/1 (Thr202/Tyr204) Polyclonal Antibody molecular weight