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Hydrocortisone cypionate

Name: Hydrocortisone cypionate
Brand: TargetMol
SKU: T19358
Rating: 4.5 (1 reviews)

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Catalog No. T19358Cas No. 508-99-6

Hydrocortisone cypionate is a corticosteroid ester and synthetic glucocorticoid corticosteroid.

Hydrocortisone cypionate

😃Good

Catalog No. T19358Cas No. 508-99-6

Hydrocortisone cypionate is a corticosteroid ester and synthetic glucocorticoid corticosteroid.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	Inquiry	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

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Product Introduction

Bioactivity

Description

Hydrocortisone cypionate is a corticosteroid ester and synthetic glucocorticoid corticosteroid.

In vitro

Hydrocortisone treatment of dendritic cells (DCs) not only inhibits the production of IFN-γ but also prompts a rise in IL-4 release without affecting IL-5 levels. It mitigates postischemic oxidative stress, reduces perfusion pressure, and lowers transudate formation while preventing the postischemic release of syndecan-1, heparan sulfate, hyaluronan, and histamine from resident mast cells. At a concentration of 50 nM, hydrocortisone displays a dose-dependent reduction in GR transcript in hCMEC/D3 cells. Enhancing serum-reduced cell differentiation media with hydrocortisone significantly boosts the transendothelial electrical resistance (TER) across the hCMEC/D3 monolayer. Additionally, hydrocortisone-treated DCs exhibit suppressed expression of MHC II molecules, CD86, CD83, and a marked decrease in IL-12 secretion, showcasing its broad immunomodulatory effects.

Chemical Properties

Molecular Weight	486.64
Formula	C₂₉H₄₂O₆
Cas No.	508-99-6
Relative Density.	1.22g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (256.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.78 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0549 mL	10.2745 mL	20.5491 mL	102.7454 mL
5 mM	0.4110 mL	2.0549 mL	4.1098 mL	20.5491 mL
10 mM	0.2055 mL	1.0275 mL	2.0549 mL	10.2745 mL
20 mM	0.1027 mL	0.5137 mL	1.0275 mL	5.1373 mL
50 mM	0.0411 mL	0.2055 mL	0.4110 mL	2.0549 mL
100 mM	0.0205 mL	0.1027 mL	0.2055 mL	1.0275 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc