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Thyroid hormone receptor(THR)

The thyroid hormone receptor (TR) is a type of nuclear receptor that is activated by binding thyroid hormone.TRs act as transcription factors, ultimately affecting the regulation of gene transcription and translation. These receptors also have non-genomic effects that lead to second messenger activation, and corresponding cellular response.

  • DPC AJ1951 acetate
    TP1906L1
    DPC-AJ1951 acetate, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 acetate in ex vivo and in vivo assays of bone resorption[1].
    • $315
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  • (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate
    T9691L
    (D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate is a highly potent antagonist of parathyroid hormone (PTH) The Ki value is 69 nM in bovine renal cortical membrane.
    • $111
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  • Protirelin Acetate(24305-27-9 free base)
    T6956L
    Protirelin Acetate(24305-27-9 free base) (Thyroliberin Acetate) is a tripeptide that stimulates the release of thyrotropin and prolactin.
    • $50
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  • DS08210767
    T111012376334-75-5In house
    DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM.
    • $129
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  • Liothyronine
    T16536893-02-3
    Liothyronine (Tresitope) is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
    • $36
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  • Triiodothyronine Sulfate
    T2901131135-55-4
    Triiodothyronine Sulfate is a prodrug to the Conventional Hormone Therapy of Hypothyroidism. Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone bind to β1 thyroid
    • $1,980
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  • L-Thyroxine sodium salt pentahydrate
    T156996106-07-6
    L-Thyroxine sodium salt pentahydrate, also known as Levothyroxine, is a synthetic hormone utilized in the study of hypothyroidism. It is biologically activated into Triiodothyronine (T3) from its original form, L-Thyroxine (T4), through conversion by DIO enzymes.
    • $50
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  • Glutaurine aceate
    T25455L
    Glutaurine aceate containing glutamine and taurine residues is an orally active hormone of the parathyroid. Glutaurine aceate, as a hormone, is isolated from parathyroid gland oxyphil cells. Glutaurine aceate can be used for the research of antiepileptic and anti-amnesia[1][2][3][4].
    • $50
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  • 2-Thiouracil
    T1310141-90-2
    2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
    • $29
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  • 3,5-Diiodo-L-thyronine
    T44611041-01-6
    3,5-Diiodo-L-thyronine (Diiodothyronine) is an iodinated thyronine hormone that regulates gene activity affecting processes such as homeostasis, lipid metabolism and insulin resistance.
    • $39
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  • Carbimazole
    T095222232-54-8
    Carbimazole (Athyromazole) is an Imidazolium thyroid antagonist, which is rapidly transformed into MMI in vivo and can be converted into methidazole in vitro, and can be used in the study of Graves' disease.
    • $46
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  • Tiratricol
    T160451-24-1
    Tiratricol (3,3',5-Triiodothyroacetic acid) is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of Allan-Herndon-Dudley Syndrome.
    • $33
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  • TR antagonist 1
    T13435500794-88-7
    TR antagonist 1 is a highly potent thyroid hormone receptor (TR) antagonist (IC50 of 36 and 22 nM for TRα and TRβ, respectively) that can be used to study diseases caused by endocrine abnormalities.
    • $262
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  • MB-07811
    T16018852948-13-1
    MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344 with cholesterol and triglycerides lowering activity. MB-07811 is an agonist of liver-targeted THR-β.
    • $158
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  • Taltirelin
    T7590103300-74-9
    Taltirelin (TA-0910) is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))[1].
    • $59
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  • NH-3
    T40548447415-26-1
    NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.
    • $229
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  • Sobetirome
    T5313211110-63-3
    Sobetirome (IACS-010759) is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).
    • $41
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  • Resmetirom
    T3595920509-32-6
    Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist.
    • $33
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  • Protirelin Acetate
    TP1022120876-23-5
    Protirelin Acetate (TRH Acetate) is a thyrotropin-releasing hormone, stimulating the release of thyrotropin and prolactin from the anterior pituitary.
    • $40
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  • Liothyronine sodium
    T166955-06-1
    Liothyronine Sodium is the sodium salt form of liothyronine, a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyronine (T3). Liothyronine sodium (3,3',5-Triiodo-L-thyronine sodium) binds to nuclear thyroid receptors which then bind to thyroid hormone response elements of target genes. As a result, liothyronine sodium induces gene expression that is required for normal growth and development. Liothyronine sodium is more potent and has a more rapid action than thyroxine (T4).
    • $47
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  • Parathyroid Hormone (1-34), bovine
    T2153512583-68-5
    Parathyroid Hormone (1-34), bovine is a parathyroid hormone (PTH) receptor agonist that is part of the parathyroid hormone family. Parathyroid Hormone (1-34), bovine is used to study osteoporosis and hypoparathyroidism.
    • $89
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  • Methimazole
    T084060-56-0
    Methimazole (Thiamazole) is an antithyroid compound with significant hepatotoxicity and is often used in the study of hyperthyroidism.
    • $45
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  • CO23
    T108551370363-74-8
    CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.
    • $277
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  • Eprotirome
    T5360355129-15-6
    Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.
    • $158
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  • L-Thyroxine
    T086451-48-9
    L-Thyroxine (NSC 36397) is the major hormone derived from the thyroid gland. L-Thyroxine (NSC 36397) is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. L-Thyroxine (NSC 36397) is released from thyroglobulin by proteolysis and secreted into the blood. L-Thyroxine (NSC 36397) is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
    • $31
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  • Propylthiouracil
    T130951-52-5
    Propylthiouracil (6-n-Propylthiouracil) is a thyroid peroxidase inhibitor and also a 5' -deiodinase inhibitor.
    • $33
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  • KAT681
    T15644373641-87-3
    KAT681 is a liver selective thyromimetic.
    • $1,520
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  • L-Thyroxine sodium
    T2235555-03-8
    L-Thyroxine sodium (LT4 sodium), the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.
    • -$2
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  • 3,5-Diiodothyropropionic acid
    T134921158-10-7
    3,5-Diiodothyropropionic acid (C082182) is a thyroid hormone analog. It induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (Ka: 2.40/M and 4.06/M for TRα1 and TRβ1).
    • $39
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  • Taltirelin acetate
    T130721549593-23-8
    Taltirelin acetate (TA-0910 acetate) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R)(IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release)).
    • $30
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  • Protirelin
    T695624305-27-9
    Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.
    • $47
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  • AH-3960
    T23673862907-48-0
    AH-3960 is an thyroid hormone receptor-1 (PTHR1) agonist.
    • $54
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  • REVERSE T3
    T75785817-39-0
    Reverse T3 (3,3',5'-triiodo-L-thyronine) inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.
    • $42
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  • 2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE
    T867224038-68-4
    2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE is targets the thyroid stimulating hormone receptor (human)
    • $50
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  • PCO371
    T164421613373-33-3
    PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) is an orally active full agonist of parathyroid hormone receptor 1. It has no effect on PTH type 2 receptor.
    • $97
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