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Thyroid hormone receptor(THR)

The thyroid hormone receptor (TR) is a type of nuclear receptor that is activated by binding thyroid hormone.TRs act as transcription factors, ultimately affecting the regulation of gene transcription and translation. These receptors also have non-genomic effects that lead to second messenger activation, and corresponding cellular response.

PCO371
T164421613373-33-3
PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) is an orally active full agonist of parathyroid hormone receptor 1. It has no effect on PTH type 2 receptor.
  • $97
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Resmetirom
T3595920509-32-6
Resmetirom (VIA-3196) is a highly selective thyroid hormone receptor β (THR-β) agonist.
  • $33
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REVERSE T3
T75785817-39-0
Reverse T3 (3,3',5'-triiodo-L-thyronine) inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.
  • $42
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Azetirelin
T3026995729-65-0In house
Azetirelin (YM 14673) is a new thyrotropin-releasing hormone (TRH) analog.
  • $1,520
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MB-07811
T16018852948-13-1
MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB-07344, known for its cholesterol and triglycerides lowering activity and its function as a liver-targeted THR-β agonist.
  • $95
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3,5-Diiodothyropropionic acid
T134921158-10-7
3,5-Diiodothyropropionic acid (C082182) is a thyroid hormone analog. It induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (Ka: 2.40 M and 4.06 M for TRα1 and TRβ1).
  • $39
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NH-3
T40548447415-26-1
NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.
  • $229
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Sobetirome
T5313211110-63-3
Sobetirome (IACS-010759) is a selective agonist of thyroid hormone receptor β (TRβ) and binds selectively to TRβ-1 (EC50: 0.16 μM).
  • $41
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Protirelin Acetate
TP1022120876-23-5
Protirelin Acetate (TRH Acetate) is a thyrotropin-releasing hormone, stimulating the release of thyrotropin and prolactin from the anterior pituitary.
  • $40
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Liothyronine sodium
T166955-06-1
Liothyronine Sodium is the sodium salt form of liothyronine, a synthetic form of the levorotatory isomer of the naturally occurring thyroid hormone triiodothyronine (T3). Liothyronine sodium (3,3',5-Triiodo-L-thyronine sodium) binds to nuclear thyroid receptors which then bind to thyroid hormone response elements of target genes. As a result, liothyronine sodium induces gene expression that is required for normal growth and development. Liothyronine sodium is more potent and has a more rapid action than thyroxine (T4).
  • $47
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DS08210767
T111012376334-75-5In house
DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with an IC50 of 90 nM.
  • $129
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AH-3960
T23673862907-48-0
AH-3960 is an thyroid hormone receptor-1 (PTHR1) agonist.
  • $52
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Protirelin
T695624305-27-9
Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.
  • $47
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TR antagonist 1
T13435500794-88-7
TR antagonist 1 is a highly potent thyroid hormone receptor (TR) antagonist (IC50 of 36 and 22 nM for TRα and TRβ, respectively) that can be used to study diseases caused by endocrine abnormalities.
  • $299
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3,5-Diiodo-L-thyronine
T44611041-01-6
3,5-Diiodo-L-thyronine (Diiodothyronine) is an iodinated thyronine hormone that regulates gene activity affecting processes such as homeostasis, lipid metabolism and insulin resistance.
  • $29
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Propylthiouracil
T130951-52-5
Propylthiouracil (6-n-Propylthiouracil) is a thyroid peroxidase inhibitor and also a 5' -deiodinase inhibitor.
  • $33
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Tiratricol
T160451-24-1
Tiratricol (3,3',5-Triiodothyroacetic acid) is a metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of Allan-Herndon-Dudley Syndrome.
  • $33
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2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE
T867224038-68-4
2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE is targets the thyroid stimulating hormone receptor (human)
  • $50
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L-Thyroxine sodium
T2235555-03-8
L-Thyroxine sodium (LT4 sodium), the major hormone derived from the thyroid gland, is the agonist of Thyroid hormone receptor alpha and beta.
  • $47
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Protirelin Acetate(24305-27-9 free base)
T6956L
Protirelin Acetate(24305-27-9 free base) (Thyroliberin Acetate) is a tripeptide that stimulates the release of thyrotropin and prolactin.
  • $50
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Liothyronine sodium hydrate
T64268345957-19-9
Liothyronine sodium hydrate (Triiodothyronine sodium hydrate) is a TRα and TRβ agonist and a thyroxine analog with anticancer and antitumor activities. It can be used to study hypothyroidism, stroke and cognitive dysfunction.
  • $36
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Eprotirome
T5360355129-15-6
Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.
  • $95
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Taltirelin acetate
T130721549593-23-8
Taltirelin acetate (TA-0910 acetate) is a superagonist of the thyrotropin-releasing hormone receptor (TRH-R), with an IC50 of 910 nM and an EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release).
  • $30
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Methimazole
T084060-56-0
Methimazole (Thiamazole) is an antithyroid compound with significant hepatotoxicity and is often used in the study of hyperthyroidism.
  • $45
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DPC AJ1951 acetate
TP1906L1
DPC-AJ1951 acetate, a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). And characterized the activity of DPC-AJ1951 acetate in ex vivo and in vivo assays of bone resorption[1].
  • $189
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Carbimazole
T095222232-54-8
Carbimazole (Athyromazole) is an Imidazolium thyroid antagonist, which is rapidly transformed into MMI in vivo and can be converted into methidazole in vitro, and can be used in the study of Graves' disease.
  • $35
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2-Thiouracil
T1310141-90-2
2-Thiouracil (Deracil) is a thiolated uracil derivative that is a known anti-hyperthyroid agent.
  • $29
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CO23
T108551370363-74-8
CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development.
  • $233
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L-Thyroxine sodium salt pentahydrate
T156996106-07-6
L-Thyroxine sodium salt pentahydrate (Sodium levothyroxine pentahydrate) is a thyroid hormone with anticholesterol activity that inhibits the release of thyroid hormones from thyroid cancer nodules and is used in immune and endocrine disorders such as hypothyroidism, myxedema, cretinism and obesity. diseases, such as hypothyroidism, myxedema, cretinism and obesity.
  • $30
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Parathyroid Hormone (1-34), bovine
T2153512583-68-5
Parathyroid Hormone (1-34), bovine, a parathyroid hormone (PTH) receptor agonist from the parathyroid hormone family, is used to study osteoporosis and hypoparathyroidism.
  • $89
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(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate
T9691L
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate is a highly potent antagonist of parathyroid hormone (PTH) The Ki value is 69 nM in bovine renal cortical membrane.
  • $67
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Triiodothyronine Sulfate
T2901131135-55-4
Triiodothyronine Sulfate is a prodrug to the Conventional Hormone Therapy of Hypothyroidism. Triiodothyronine sulfate is the main metabolite of thyroid hormone triiodothyronine (T3). Triiodothyronine is an active form of thyroid hormone bind to β1 thyroid
  • $1,980
6-8 weeks
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Taltirelin
T7590103300-74-9
Taltirelin (TA-0910) is at thyrotropin-releasing hormone receptor (TRH-R) superagonist (IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca2+ concentration (Ca2+ release))[1].
  • $59
5 days
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Glutaurine aceate
T25455L
Glutaurine aceate containing glutamine and taurine residues is an orally active hormone of the parathyroid. Glutaurine aceate, as a hormone, is isolated from parathyroid gland oxyphil cells. Glutaurine aceate can be used for the research of antiepileptic and anti-amnesia[1][2][3][4].
  • $50
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KAT681
T15644373641-87-3
KAT681 is a liver selective thyromimetic.
  • $1,520
6-8 weeks
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