BF-168

Name: BF-168
Brand: TargetMol
SKU: T10529
Rating: 4.5 (1 reviews)

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Catalog No. T10529Cas No. 634911-47-0

BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).

BF-168

😃Good

Catalog No. T10529Cas No. 634911-47-0

BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$376	10-14 weeks	10-14 weeks
25 mg	$1,140	10-14 weeks	10-14 weeks
50 mg	$1,490	10-14 weeks	10-14 weeks
100 mg	$2,360	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).
Targets&IC50	β-Amyloid (1–42):ki： 6.4 nM
In vitro	BF-168 is a potent agent that selectively recognizes SPs and NFTs in AD brain. BF-168 is a candidate probe for PET and is found to specifically recognize both neuritic and diffuse plaques.
In vivo	Intravenous injection of BF-168 in PS1/APP and APP23 transgenic mice results in specific in vivo labeling of both compact and diffuse amyloid deposits in the brain. Additionally, 18F-radiolabeled BF-168 demonstrates significant initial brain uptake (3.9% injected dose/gm at 2 min post-injection) and rapid clearance (t1/2=24.7 min) after intravenous administration in normal mice.

Chemical Properties

Molecular Weight	312.34
Formula	C₁₈H₁₇FN₂O₂
Cas No.	634911-47-0
Smiles	CNc1ccc(\C=C\c2nc3ccc(OCCF)cc3o2)cc1
Relative Density.	1.258 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc