BF-168

Name: BF-168
Brand: TargetMol
SKU: T10529
Rating: 4.5 (1 reviews)

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Catalog No. T10529Cas No. 634911-47-0

BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).

BF-168

😃Good

Catalog No. T10529Cas No. 634911-47-0

BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$376	10-14 weeks	10-14 weeks
25 mg	$1,140	10-14 weeks	10-14 weeks
50 mg	$1,490	10-14 weeks	10-14 weeks
100 mg	$2,360	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).
Targets&IC50	β-Amyloid (1–42):ki： 6.4 nM
In vitro	BF-168 is a potent agent that selectively recognizes SPs and NFTs in AD brain. BF-168 is a candidate probe for PET and is found to specifically recognize both neuritic and diffuse plaques.
In vivo	Intravenous injection of BF-168 in PS1/APP and APP23 transgenic mice results in specific in vivo labeling of both compact and diffuse amyloid deposits in the brain. Additionally, 18F-radiolabeled BF-168 demonstrates significant initial brain uptake (3.9% injected dose/gm at 2 min post-injection) and rapid clearance (t1/2=24.7 min) after intravenous administration in normal mice.

Chemical Properties

Molecular Weight	312.34
Formula	C₁₈H₁₇FN₂O₂
Cas No.	634911-47-0
Relative Density.	1.258 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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