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Cinanserin hydrochloride

Name: Cinanserin hydrochloride
Brand: TargetMol
SKU: T14968
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14968Cas No. 54-84-2

Alias SQ 10643

Cinanserin hydrochloride (SQ 10643), a high-affinity antagonist of the 5-HT2 receptor (Ki: 41 nM), is also a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus.

Cinanserin hydrochloride

🥰Excellent

Purity: 99.57%

Catalog No. T14968Alias SQ 10643Cas No. 54-84-2

Cinanserin hydrochloride (SQ 10643), a high-affinity antagonist of the 5-HT2 receptor (Ki: 41 nM), is also a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
5 mg	$68	-	In Stock
10 mg	$109	-	In Stock
25 mg	$218	-	In Stock
50 mg	$397	-	In Stock
100 mg	$597	-	In Stock
1 mL x 10 mM (in DMSO)	$119	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.57%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Cinanserin hydrochloride (SQ 10643), a high-affinity antagonist of the 5-HT2 receptor (Ki: 41 nM), is also a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus.
Targets&IC50	5-HT2 receptor:41 nM (ki), 3CLpro:
In vitro	Cinanserin and Cinanserin hydrochloride inhibit the catalytic activity of SARS-CoV 3CLpro and HCoV-229E 3CLpro (IC50: 4.68 μM and 5.68 μM). Cinanserin/Cinanserin hydrochloride has a binding affinity to SARS-CoV 3CLpro, HCoV-229E 3CLpro, with the KD values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CLpro[1].
In vivo	Cinanserin (5 mg/kg; intravenous injection; 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels[2].
Synonyms	SQ 10643

Chemical Properties

Molecular Weight	376.94
Formula	C₂₀H₂₅ClN₂OS
Cas No.	54-84-2
Smiles	Cl.CN(C)CCCSc1ccccc1NC(=O)C=Cc1ccccc1
Relative Density.	1.22 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (331.62 mM), Sonication is recommended.

H2O: 100 mg/mL (265.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6529 mL	13.2647 mL	26.5294 mL	132.6471 mL
5 mM	0.5306 mL	2.6529 mL	5.3059 mL	26.5294 mL
10 mM	0.2653 mL	1.3265 mL	2.6529 mL	13.2647 mL
20 mM	0.1326 mL	0.6632 mL	1.3265 mL	6.6324 mL
50 mM	0.0531 mL	0.2653 mL	0.5306 mL	2.6529 mL
100 mM	0.0265 mL	0.1326 mL	0.2653 mL	1.3265 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc