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Glychionide A

Name: Glychionide A
Brand: TargetMol
SKU: TN1700
Price: 139 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1700Cas No. 119152-50-0

Glychionide A is a flavonoid glycoside discovered in Glycyrrhiza glabra that exhibits antitumor activity against PANC-1 cells by inducing autophagy, apoptosis, cell cycle arrest, and disruption of mitochondrial membrane potential.

Glychionide A

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Purity: 99.82%

Catalog No. TN1700Cas No. 119152-50-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$139	-	In Stock
5 mg	$347	-	In Stock
10 mg	$515	-	In Stock
25 mg	$823	-	In Stock
50 mg	$1,090	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

In vitro

Glychionide A (3.12-100 μmol/L) significantly inhibited the proliferation of pancreatic carcinoma PANC-1 cells (IC50=14 μmol/L) [1].
Glychionide A (7-28 μmol/L) simultaneously induced autophagy and apoptosis in pancreatic carcinoma cells [1].
Glychionide A (7-28 μmol/L) caused G2/M phase cell cycle arrest in pancreatic carcinoma PANC-1 cells [1].
Glychionide A (7-28 μmol/L) induced ROS production in pancreatic carcinoma PANC-1 cells [1].

Chemical Properties

Molecular Weight	446.36
Formula	C₂₁H₁₈O₁₁
Cas No.	119152-50-0
Smiles	O=C1C=2C(OC(=C1)C3=CC=CC=C3)=C(O)C(O[C@@H]4O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]4O)=CC2O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (179.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2403 mL	11.2017 mL	22.4034 mL	112.0172 mL
5 mM	0.4481 mL	2.2403 mL	4.4807 mL	22.4034 mL
10 mM	0.2240 mL	1.1202 mL	2.2403 mL	11.2017 mL
20 mM	0.1120 mL	0.5601 mL	1.1202 mL	5.6009 mL
50 mM	0.0448 mL	0.2240 mL	0.4481 mL	2.2403 mL
100 mM	0.0224 mL	0.1120 mL	0.2240 mL	1.1202 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc