PC-Biotin-PEG4-NHS carbonate

Name: PC-Biotin-PEG4-NHS carbonate
Brand: TargetMol
SKU: T18519
Rating: 4.5 (1 reviews)

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Catalog No. T18519Cas No. 2055198-03-1

PC-Biotin-PEG4-NHS carbonate, a polyethylene glycol (PEG) derived linker, is utilized in the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

PC-Biotin-PEG4-NHS carbonate

😃Good

Catalog No. T18519Cas No. 2055198-03-1

PC-Biotin-PEG4-NHS carbonate, a polyethylene glycol (PEG) derived linker, is utilized in the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

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Product Introduction

Bioactivity

Description	PC-Biotin-PEG4-NHS carbonate, a polyethylene glycol (PEG) derived linker, is utilized in the synthesis of proteolysis-targeting chimeras (PROTACs) [1].
In vitro	PROTACs consist of two distinct ligands joined by a linker: one binding to an E3 ubiquitin ligase and the other to the target protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].

Chemical Properties

Molecular Weight	810.87
Formula	C₃₅H₅₀N₆O₁₄S
Cas No.	2055198-03-1
Smiles	C(CCCC(NCCOCCOCCOCCOCCC(NCC1=CC(C(OC(ON2C(=O)CCC2=O)=O)C)=C(N(=O)=O)C=C1)=O)=O)[C@H]3[C@@]4([C@](CS3)(NC(=O)N4)[H])[H]
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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