c-Met-IN-2

Name: c-Met-IN-2
Brand: TargetMol
SKU: T10654
Rating: 4.5 (1 reviews)

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Catalog No. T10654Cas No. 1635406-73-3

c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) exhibiting antitumor activity.

c-Met-IN-2

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Catalog No. T10654Cas No. 1635406-73-3

c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) exhibiting antitumor activity.

Pack Size	Price	Availability
25 mg	$2,270	3-6 months
50 mg	$2,980	3-6 months
100 mg	$4,000	3-6 months

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Product Introduction

Bioactivity

Description	c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) exhibiting antitumor activity.
Targets&IC50	c-Met:0.6 nM
In vitro	c-Met-IN-2 (Compound 14) exhibits weak activity on other kinases, with IC50 values of 731 nM [RON], 1075 nM [AxI], 18364 nM [VEGFR2], 2357 nM [PDGFRa], 5396 nM [c-Kit], and 17056 nM [c-Src].
In vivo	In mice bearing H1993 tumors, c-Met-IN-2 (0.1, 1, 10 mg/kg, p.o., once daily) significantly reduces the volume of tumors. c-Met-IN-2 has a similar effect in SNU-5 xenograft model via oral administration at 0.3, 1 and 3 mg/kg.

Chemical Properties

Molecular Weight	484.49
Formula	C₂₄H₂₁FN₁₀O
Cas No.	1635406-73-3
Relative Density.	1.55 g/cm3 (Predicted)

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

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