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G108

Name: G108
Brand: TargetMol
SKU: T69663
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T69663Cas No. 2369750-66-1

Alias G-108, G 108

G108 is an inhibitor of human cGAS and is used in the study of autoimmune diseases associated with human cGAS.

G108

🥰Excellent

Purity: 99.75%

Catalog No. T69663Alias G-108, G 108Cas No. 2369750-66-1

G108 is an inhibitor of human cGAS and is used in the study of autoimmune diseases associated with human cGAS.

Pack Size	Price	Availability
1 mg	$490	In Stock
5 mg	$1,130	In Stock
10 mg	$1,530	In Stock
25 mg	$2,270	In Stock
50 mg	$2,970	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.75%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	G108 is an inhibitor of human cGAS and is used in the study of autoimmune diseases associated with human cGAS.
Synonyms	G-108, G 108

Chemical Properties

Molecular Weight	365.21
Formula	C₁₆H₁₄Cl₂N₄O₂
Cas No.	2369750-66-1
Smiles	O=C(N1CC=2C=3C(=CC(Cl)=C(Cl)C3NC2CC1)C=4C=NNC4)CO
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 120 mg/mL (210.87 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.7382 mL	13.6908 mL	27.3815 mL	136.9075 mL
5 mM	0.5476 mL	2.7382 mL	5.4763 mL	27.3815 mL
10 mM	0.2738 mL	1.3691 mL	2.7382 mL	13.6908 mL
20 mM	0.1369 mL	0.6845 mL	1.3691 mL	6.8454 mL
50 mM	0.0548 mL	0.2738 mL	0.5476 mL	2.7382 mL
100 mM	0.0274 mL	0.1369 mL	0.2738 mL	1.3691 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc