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G108

Name: G108
Brand: TargetMol
SKU: T69663
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T69663Cas No. 2369750-66-1

Alias G-108, G 108

G108 is an inhibitor of human cGAS and is used in the study of autoimmune diseases associated with human cGAS.

G108

🥰Excellent

Purity: 99.75%

Catalog No. T69663Alias G-108, G 108Cas No. 2369750-66-1

G108 is an inhibitor of human cGAS and is used in the study of autoimmune diseases associated with human cGAS.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$490	In Stock	In Stock
5 mg	$1,130	In Stock	In Stock
10 mg	$1,530	In Stock	In Stock
25 mg	$2,270	In Stock	In Stock
50 mg	$2,970	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.75%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	G108 is an inhibitor of human cGAS and is used in the study of autoimmune diseases associated with human cGAS.
Synonyms	G-108, G 108

Chemical Properties

Molecular Weight	365.21
Formula	C₁₆H₁₄Cl₂N₄O₂
Cas No.	2369750-66-1
Smiles	O=C(N1CC=2C=3C(=CC(Cl)=C(Cl)C3NC2CC1)C=4C=NNC4)CO

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 120 mg/mL (328.58 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.7382 mL	13.6908 mL	27.3815 mL	136.9075 mL
5 mM	0.5476 mL	2.7382 mL	5.4763 mL	27.3815 mL
10 mM	0.2738 mL	1.3691 mL	2.7382 mL	13.6908 mL
20 mM	0.1369 mL	0.6845 mL	1.3691 mL	6.8454 mL
50 mM	0.0548 mL	0.2738 mL	0.5476 mL	2.7382 mL
100 mM	0.0274 mL	0.1369 mL	0.2738 mL	1.3691 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc