Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LSD1-IN-25 (Compound 9j) is a potent, selective, and orally active inhibitor of LSD1, exhibiting an IC50 of 46 nM (Ki = 30.3 nM) and capable of inducing apoptosis in cancer cells [1].
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Description | LSD1-IN-25 (Compound 9j) is a potent, selective, and orally active inhibitor of LSD1, exhibiting an IC50 of 46 nM (Ki = 30.3 nM) and capable of inducing apoptosis in cancer cells [1]. |
Targets&IC50 | LSD1:46 nM, LSD1:30.3 nM (Ki) |
In vitro | LSD1-IN-25 (Compound 9j; 0-20 μM; 72 h) inhibits the proliferation of solid tumor cells [1]. At concentrations of 1-4 μM and a 24-hour exposure, LSD1-IN-25 induces an increase in H3K4me2 levels and inhibits the epithelial-mesenchymal transition (EMT) process in H1650 cells [1]. Additionally, LSD1-IN-25 (1-4 μM; 24 h) induces apoptosis and S-phase arrest in H1650 cells [1]. |
In vivo | LSD1-IN-25 (Compound 9j; 10 and 20 mg/kg; oral gavage; daily for 21 days) demonstrated antitumor activity in a H1650 cell xenograft mouse model [1]. |
Molecular Weight | 617.16 |
Formula | C32H33ClN6O3S |
CAS No. | 2911585-60-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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LSD1-IN-25 2911585-60-7 Chromatin/Epigenetic Histone Demethylase inhibitor inhibit