Vinconate

Name: Vinconate
Brand: TargetMol
SKU: T13959
Rating: 4.5 (1 reviews)

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Catalog No. T13959Cas No. 70704-03-9

Alias Chanodesethylapovincamine

Vinconate, an indolonaphthyridine derivative, can stimulate the muscarinic acetylcholine receptor.

Vinconate

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Catalog No. T13959Alias ChanodesethylapovincamineCas No. 70704-03-9

Vinconate, an indolonaphthyridine derivative, can stimulate the muscarinic acetylcholine receptor.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Vinconate, an indolonaphthyridine derivative, can stimulate the muscarinic acetylcholine receptor.
In vivo	In dialysate dopamine concentrations significantly increased by Vinconate (50 to 200 mg/kg p.o.). Daily treatment with Vinconate (25 mg/kg) for 7 days also significantly increases dopamine and serotonin concentrations in dialysate[1]. In [3H]QNB binding in the nucleus accumbens and cerebellum, Chronic treatment with Vinconate at a 10 mg/kg significantly ameliorats the reduction . Furthermore, this Vinconate treatment significantly enhances [3H]QNB binding in the frontal cortex and hippocampus compare with the vehicle-treated aged animals. Also, chronic treatment with Vinconate at the higher dose significantly elevates [3H]QNB binding in the hippocampal CA3 sector and dentate gyrus compare with the vehicle-treated aged animals. Chronic treatment with Vinconate at a dose of 10 mg/kg shows a significant reduction in [3H]HC binding only in the hippocampal CA1 sector compare with the vehicle-treated aged rats[2].
Synonyms	Chanodesethylapovincamine

Chemical Properties

Molecular Weight	296.36
Formula	C₁₈H₂₀N₂O₂
Cas No.	70704-03-9
Smiles	C(OC)(=O)C=1N2C3=C(C=4C2=CC=CC4)CCN(CC)C3CC1
Relative Density.	1.27g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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