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Progerinin
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Catalog No. T201315Cas No. 2249696-72-6
Alias SLC-D011, SLCD011
Progerinin (SLC-D011) is an orally active progerin-lamin A binding inhibitor that alleviates nuclear deformation and growth arrest, suitable for studying Hutchinson-Gilford progeria syndrome (HGPS).
Progerinin
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Catalog No. T201315Alias SLC-D011, SLCD011Cas No. 2249696-72-6
Progerinin (SLC-D011) is an orally active progerin-lamin A binding inhibitor that alleviates nuclear deformation and growth arrest, suitable for studying Hutchinson-Gilford progeria syndrome (HGPS).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $132 | - | In Stock | |
| 5 mg | $315 | - | In Stock | |
| 10 mg | $498 | - | In Stock | |
| 25 mg | $996 | - | In Stock | |
| 50 mg | $1,590 | - | In Stock | |
| 100 mg | $2,550 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Appearance:Solid
Color:Yellow
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| Description | Progerinin (SLC-D011) is an orally active progerin-lamin A binding inhibitor that alleviates nuclear deformation and growth arrest, suitable for studying Hutchinson-Gilford progeria syndrome (HGPS). |
| In vitro | In HGPS patient-derived fibroblasts (e.g., AG11498), Progerinin (100 nM, 3 days) significantly reduced progerin expression and induced the expression of H3K9me3 and cell cycle protein Cyclin B1 [1]. In various HGPS cells (e.g., AG11513, AG11498), Progerinin (2 μM, 7 days) decreased progerin and p16/INK4A expression while increasing H3K9me3 levels [1]. |
| In vivo | In LmnaG609G/G609G mice, intraperitoneal injection of Progerinin (20 mg/kg, twice weekly) increased body weight and extended lifespan to 21 weeks; oral administration (50 mg/kg, once daily) also increased body weight and prolonged lifespan [1]. |
| Synonyms | SLC-D011, SLCD011 |
| Molecular Weight | 362.42 |
| Formula | C23H22O4 |
| Cas No. | 2249696-72-6 |
| Smiles | CC1(C)OC=2C(=CC3=C(C2)OC(=O)C=C3)C[C@@H]1OC/C=C/C4=CC=CC=C4 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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