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Cyclen

Name: Cyclen
Brand: TargetMol
SKU: TJS1183
Rating: 4.5 (1 reviews)

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Catalog No. TJS1183Cas No. 294-90-6

Alias 1,4,7,10-tetraazacyclododecane

Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocycle capable of selectively binding cations that used as a ligand in chemistry for instance with chemicals used in MRI contrast agents.

Cyclen

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Catalog No. TJS1183Alias 1,4,7,10-tetraazacyclododecaneCas No. 294-90-6

Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocycle capable of selectively binding cations that used as a ligand in chemistry for instance with chemicals used in MRI contrast agents.

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1 g	$29	Backorder

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Batch Information

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Purity:≥95%

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	Cyclen (1,4,7,10-tetraazacyclododecane) is a macrocycle capable of selectively binding cations that used as a ligand in chemistry for instance with chemicals used in MRI contrast agents.
Synonyms	1,4,7,10-tetraazacyclododecane

Chemical Properties

Molecular Weight	172.27
Formula	C₈H₂₀N₄
Cas No.	294-90-6
Smiles	C1CNCCNCCNCCN1
Relative Density.	1.13 Corresponds to D4(20). Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 105 mg/mL (609.51 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	5.8048 mL	29.0242 mL	58.0484 mL	290.2421 mL
5 mM	1.1610 mL	5.8048 mL	11.6097 mL	58.0484 mL
10 mM	0.5805 mL	2.9024 mL	5.8048 mL	29.0242 mL
20 mM	0.2902 mL	1.4512 mL	2.9024 mL	14.5121 mL
50 mM	0.1161 mL	0.5805 mL	1.1610 mL	5.8048 mL
100 mM	0.0580 mL	0.2902 mL	0.5805 mL	2.9024 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc