PCSK9 autophagic degrader 2

Name: PCSK9 autophagic degrader 2
Brand: TargetMol
SKU: T206701
Rating: 4.5 (1 reviews)

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Catalog No. T206701Cas No. 2974497-11-3

PCSK9 autophagic degrader 2 (W6) is an autophagosome-targeting agent for PCSK9, with a DC50 value of 20.6 nM. It exhibits effects comparable to anti-atherosclerotic treatments and has a binding constant (KD) with LC3B of 2.5 μM.

PCSK9 autophagic degrader 2

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Catalog No. T206701Cas No. 2974497-11-3

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Product Introduction

Bioactivity

Description	PCSK9 autophagic degrader 2 (W6) is an autophagosome-targeting agent for PCSK9, with a DC50 value of 20.6 nM. It exhibits effects comparable to anti-atherosclerotic treatments and has a binding constant (KD) with LC3B of 2.5 μM.
In vitro	PCSK9 autophagic degrader 2 (W6) degrades PCSK9 by linking it with LC3B and utilizing the autophagic pathway.

Chemical Properties

Molecular Weight	1012.54
Formula	C₃₉H₄₁Br₂IN₄O₈S
Cas No.	2974497-11-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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