IL-4 Protein, Rat, Recombinant (His)

Name: IL-4 Protein, Rat, Recombinant (His)
Brand: TargetMol
SKU: TMPS-00080
Price: 138 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: TCGF-2, T cell growth factor-2, MCGF-2, Mast-cell growth factor-2, IL4, BSF-1, BCGF-1, BCDF, B cell stimulatory factor-1, B cell growth factor-1, B cell differentiation factor) Copy Product Info

Synonyms: TCGF-2, T cell growth factor-2, MCGF-2, Mast-cell growth factor-2, IL4, BSF-1, BCGF-1, BCDF, B cell stimulatory factor-1, B cell growth factor-1, B cell differentiation factor

Catalog No. TMPS-00080 Copy Product Info

IL-4 Protein, Rat, Recombinant (His) is expressed in CHO Cells. The accession number is P20096.

Pack Size	Price	USA Stock	Global Stock
5 µg	$138	-	In Stock
10 µg	$187	-	In Stock
25 µg	$283	-	In Stock
100 µg	$623	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:> 95% as analyzed by SDS-PAGE

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	ED 50 < 0.2 μg/ml, measured in a proliferationassay using C6 cells.
Description	IL-4 Protein, Rat, Recombinant (His) is expressed in CHO Cells. The accession number is P20096.
Species	Rat
Expression System	CHO Cells
Tag	His
Accession Number	P20096
Construction	His23-Ser147
Protein Purity	> 95% as determined by SDS-PAGE
Endotoxin	< 0.2 EU/μg of protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	TCGF-2, T cell growth factor-2, MCGF-2, Mast-cell growth factor-2, IL4, BSF-1, BCGF-1, BCDF, B cell stimulatory factor-1, B cell growth factor-1, B cell differentiation factor
Research Background	Interleukin-4 (IL-4) is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. It has important effects on the growth and differentiation of different immunologically competent cells. Interleukin-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of native CD4 + T cells (Th0 cells) into helper Th2 cells, and regulates the immunoglobulin class switching to the IgG1 and IgE isotypes. IL-4 has numerous important biological functions including stimulating B-cells activation, T-cell proliferation and CD4 + T-cells differentiation to Th2 cells. It is a key regulator in hormone control and adaptive immunity. IL-4 also plays a major role in inflammation response and wound repair via activation of macrophage into M2 cells. IL-4 is stabilized by three disulphide bonds forming a compact globular protein structure. Four alpha-helix bundle with left-handed twist is dominated half of the protein structure with 2 overhand connections and fall into a 2-stranded anti-parallel beta sheet.

Chemical Properties

Molecular Weight

18~22 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.