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1,4-Dihydroxy-2-naphthoic acid

Name: 1,4-Dihydroxy-2-naphthoic acid
Brand: TargetMol
SKU: TN7579
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN7579 Copy Product Info

Purity: 98.65%

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1,4-Dihydroxy-2-naphthoic acid is a bacterially derived metabolite that functions as an aryl hydrocarbon receptor (AhR) agonist and has been reported to possess anti-inflammatory activity. The ability of 1,4-Dihydroxy-2-naphthoic acid to modulate AhR signaling pathways supports the use of 1,4-Dihydroxy-2-naphthoic acid in investigations of host–microbiome interactions, inflammatory signaling networks, immune regulation, and receptor-mediated cellular responses.

Cas No. 31519-22-9

Pack Size	Price	USA Stock	Global Stock	Quantity
200 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.65%

Appearance:Solid

Color:Gray

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	1,4-Dihydroxy-2-naphthoic acid is a bacterially derived metabolite that functions as an aryl hydrocarbon receptor (AhR) agonist and has been reported to possess anti-inflammatory activity. The ability of 1,4-Dihydroxy-2-naphthoic acid to modulate AhR signaling pathways supports the use of 1,4-Dihydroxy-2-naphthoic acid in investigations of host–microbiome interactions, inflammatory signaling networks, immune regulation, and receptor-mediated cellular responses.
In vitro	Method: Young adult mouse colonic cells and human Caco-2 colon cancer cells were treated with 1,4-dihydroxy-2-naphthoic acid, and CYP1A1 and CYP1B1 mRNA levels were measured as aryl hydrocarbon receptor-responsive endpoints. Rresult: 1,4-Dihydroxy-2-naphthoic acid was the most potent compound among the tested hydroxyl- and carboxyl-substituted naphthalene derivatives and induced CYP1A1 and CYP1B1 responses comparable in magnitude to those induced by TCDD.[2] Method: RAW264.7 macrophages and bone marrow-derived macrophages obtained from IL-10-deficient mice were pretreated with 1,4-dihydroxy-2-naphthoic acid before endotoxin stimulation, and proinflammatory cytokine mRNA levels were measured. Rresult: 1,4-Dihydroxy-2-naphthoic acid significantly suppressed endotoxin-induced expression of proinflammatory cytokine mRNAs, including IL-6 and IL-23p19.[3] Method: The antiproliferative activity of 1,4-dihydroxy-2-naphthoic acid against HaCaT human keratinocytes was evaluated after 72 h of treatment using a sulforhodamine B assay. Rresult: 1,4-Dihydroxy-2-naphthoic acid inhibited HaCaT cell proliferation with an IC50 of 38.9 μg/mL.[4]
In vivo	Method: Female C57BL/6 mice were subjected to unpredictable chronic mild stress. In the preventive group, mice received 1,4-dihydroxy-2-naphthoic acid orally at 20 mg/kg daily for 3 weeks before stress exposure; in the reversal group, treatment was initiated after 2 weeks of stress. Rresult: 1,4-Dihydroxy-2-naphthoic acid prevented and reversed the stress-induced reduction in sucrose preference, indicating prevention and reversal of anhedonia-like behavior.[1] Method: Male C57BL/6 mice received 1,4-dihydroxy-2-naphthoic acid orally at 20 mg/kg daily for 3 weeks before administration of 80 mg/kg MPTP; motor function was evaluated 4 weeks later. Rresult: 1,4-Dihydroxy-2-naphthoic acid prevented MPTP-induced deficits in the motor-pole and adhesive-removal tests, improved balance-beam performance and completely prevented the MPTP-induced reduction in stride length.[5]

Chemical Properties

Molecular Weight	204.18
Formula	C₁₁H₈O₄
Cas No.	31519-22-9
Smiles	O=C(O)C=1C=C(O)C=2C=CC=CC2C1O

Storage & Solubility Information

Storage

Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 140 mg/mL (685.67 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8976 mL	24.4882 mL	48.9764 mL	244.8820 mL
5 mM	0.9795 mL	4.8976 mL	9.7953 mL	48.9764 mL
10 mM	0.4898 mL	2.4488 mL	4.8976 mL	24.4882 mL
20 mM	0.2449 mL	1.2244 mL	2.4488 mL	12.2441 mL
50 mM	0.0980 mL	0.4898 mL	0.9795 mL	4.8976 mL
100 mM	0.0490 mL	0.2449 mL	0.4898 mL	2.4488 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: 1,4-Dihydroxy-2-naphthoic acid chemical structure | 1,4-Dihydroxy-2-naphthoic acid in vivo | 1,4-Dihydroxy-2-naphthoic acid in vitro | 1,4-Dihydroxy-2-naphthoic acid formula | 1,4-Dihydroxy-2-naphthoic acid molecular weight