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Kras4B G12D-IN-1

Name: Kras4B G12D-IN-1
Brand: TargetMol
SKU: T78170
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78170Cas No. 2042365-85-3

Kras4B G12D-IN-1 is an anticancer agent that functions as an inhibitor of the Kras4B G12D protein. It effectively reduces the expression of Kras protein in mouse embryonic fibroblasts (MEFs) harboring the Kras4B G12D mutation[1].

Kras4B G12D-IN-1

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Purity: 99.75%

Catalog No. T78170Cas No. 2042365-85-3

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$89	In Stock	In Stock
5 mg	$155	In Stock	In Stock
10 mg	$255	In Stock	In Stock
25 mg	$518	In Stock	In Stock
50 mg	$828	In Stock	In Stock
100 mg	$1,260	In Stock	In Stock
500 mg	$2,530	-	In Stock
1 mL x 10 mM (in DMSO)	$173	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.75%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	372.87
Formula	C₁₆H₂₁ClN₂O₄S
Cas No.	2042365-85-3
Smiles	C(=O)(C1=C(OC)C=CC(Cl)=C1)N2C[C@@H](CNS(C=C)(=O)=O)CCC2

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (214.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6819 mL	13.4095 mL	26.8190 mL	134.0950 mL
5 mM	0.5364 mL	2.6819 mL	5.3638 mL	26.8190 mL
10 mM	0.2682 mL	1.3409 mL	2.6819 mL	13.4095 mL
20 mM	0.1341 mL	0.6705 mL	1.3409 mL	6.7047 mL
50 mM	0.0536 mL	0.2682 mL	0.5364 mL	2.6819 mL
100 mM	0.0268 mL	0.1341 mL	0.2682 mL	1.3409 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc