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Kras4B G12D-IN-1

Name: Kras4B G12D-IN-1
Brand: TargetMol
SKU: T78170
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78170Cas No. 2042365-85-3

Kras4B G12D-IN-1 is an anticancer agent that functions as an inhibitor of the Kras4B G12D protein. It effectively reduces the expression of Kras protein in mouse embryonic fibroblasts (MEFs) harboring the Kras4B G12D mutation[1].

Kras4B G12D-IN-1

🥰Excellent

Purity: 99.75%

Catalog No. T78170Cas No. 2042365-85-3

Pack Size	Price	Availability
2 mg	$89	In Stock
5 mg	$155	In Stock
10 mg	$255	In Stock
25 mg	$518	In Stock
50 mg	$828	In Stock
100 mg	$1,260	In Stock
500 mg	$2,530	In Stock
1 mL x 10 mM (in DMSO)	$173	In Stock

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Batch Information

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Purity:99.75%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	372.87
Formula	C₁₆H₂₁ClN₂O₄S
Cas No.	2042365-85-3
Smiles	C(=O)(C1=C(OC)C=CC(Cl)=C1)N2C[C@@H](CNS(C=C)(=O)=O)CCC2

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (214.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6819 mL	13.4095 mL	26.8190 mL	134.0950 mL
5 mM	0.5364 mL	2.6819 mL	5.3638 mL	26.8190 mL
10 mM	0.2682 mL	1.3409 mL	2.6819 mL	13.4095 mL
20 mM	0.1341 mL	0.6705 mL	1.3409 mL	6.7047 mL
50 mM	0.0536 mL	0.2682 mL	0.5364 mL	2.6819 mL
100 mM	0.0268 mL	0.1341 mL	0.2682 mL	1.3409 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc