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Briciclib

Name: Briciclib
Brand: TargetMol
SKU: T3207
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3207Cas No. 865783-99-9

Alias ON 014185

Briciclib (ON 014185) is a small molecule that inhibits cyclin D1 accumulation in Y cells.

Briciclib

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Purity: 99.84%

Catalog No. T3207Alias ON 014185Cas No. 865783-99-9

Briciclib (ON 014185) is a small molecule that inhibits cyclin D1 accumulation in Y cells.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
2 mg	$52	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$263	In Stock	In Stock
50 mg	$396	In Stock	In Stock
100 mg	$589	-	In Stock
500 mg	$1,280	-	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.84%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Briciclib AI Summary

Briciclib exhibits antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in both Caco-2 and VERO-6 cells at a concentration of 10 μM after 48 hours. In Caco-2 cells, the inhibition rate is 10.1%, while in VERO-6 cells, the inhibition rate is 1.03%, as determined through high content imaging. Additionally, Briciclib shows 9.538% inhibition of SARS-CoV-2 3CL-Pro protease activity at a concentration of 20 μM, based on a FRET assay. The compound also demonstrates inhibitory activity in an enzymatic assay of human HDAC6, with 6.33% inhibition using a commercial peptide substrate and 1.28% inhibition using a custom peptide substrate, indicating potential as an HDAC6 inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Briciclib (ON 014185) is a small molecule that inhibits cyclin D1 accumulation in Y cells.
Synonyms	ON 014185

Chemical Properties

Molecular Weight	474.42
Formula	C₁₉H₂₃O₁₀PS
Cas No.	865783-99-9
Smiles	C(=C/S(CC1=CC(OP(=O)(O)O)=C(OC)C=C1)(=O)=O)\C2=C(OC)C=C(OC)C=C2OC
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (105.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1078 mL	10.5392 mL	21.0784 mL	105.3918 mL
5 mM	0.4216 mL	2.1078 mL	4.2157 mL	21.0784 mL
10 mM	0.2108 mL	1.0539 mL	2.1078 mL	10.5392 mL
20 mM	0.1054 mL	0.5270 mL	1.0539 mL	5.2696 mL
50 mM	0.0422 mL	0.2108 mL	0.4216 mL	2.1078 mL
100 mM	0.0211 mL	0.1054 mL	0.2108 mL	1.0539 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc