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Pioglitazone potassium

Catalog No. T61836 CAS 1266523-09-4

Pioglitazone potassium (U 72107) is an orally active and selective agonist of peroxisome proliferator-activated receptor gamma (PPARγ). It demonstrates high affinity binding to the ligand-binding domain of PPARγ, with an EC50 of 0.93 μM and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone potassium has applications in diabetes research [2] [3] [4].

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Pioglitazone potassium Chemical Structure

Pioglitazone potassium, CAS 1266523-09-4

Pack Size	Availability	Price/USD
1 mg	35 days	$ 73.00
5 mg	35 days	$ 143.00
10 mg	35 days	$ 250.00
50 mg	35 days	$ 970.00

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Description	Pioglitazone potassium (U 72107) is an orally active and selective agonist of peroxisome proliferator-activated receptor gamma (PPARγ). It demonstrates high affinity binding to the ligand-binding domain of PPARγ, with an EC50 of 0.93 μM and 0.99 μM for human and mouse PPARγ, respectively. Pioglitazone potassium has applications in diabetes research [2] [3] [4].
In vitro	Pioglitazone potassium, at concentrations of 0.5 or 1 μM over 5 days, can effectively counteract the necrosis of β-cells and the elevation of caspase-3 activity induced by advanced glycation end-products (AGEs), thus preserving the viability of the pancreatic beta cell line HIT-T15 [2]. Additionally, a 1-hour exposure to 1 μM pioglitazone potassium enhances insulin secretion in response to low glucose levels and moderates the GSSG/GSH ratio in cells exposed to AGEs [2].
In vivo	Administered orally via gavage at doses of 10 or 30 mg/kg once daily for 14 days, Pioglitazone potassium has been shown to ameliorate insulin resistance and diabetes, potentially through mechanisms involving lipocalin in the liver, though not in skeletal muscle [3]. Furthermore, a dosage of 10 mg/kg administered daily for four weeks has notably reduced body weight, cardiac hypertrophy, high blood glucose levels, and improved dyslipidemia [4]. In ob/ob and adipo -/- ob/ob mice on a C57Bl/6 background, a dosage of 10 mg/kg did not alter serum free fatty acid and triglyceride levels nor adipocyte sizes, but a increased dosage to 30 mg/kg resulted in significant reductions. Likewise, no change was observed in the expression of TNFα and resistin in adipose tissues at 10 mg/kg, while a decrease was noted at 30 mg/kg. In male Wistar albino rats, a four-week treatment at 10 mg/kg led to decreased serum levels of creatinine and creatine kinase-MB (CK-MB), down-regulation of TGF-β1 gene expression, and adjustment in the expression of the MMP-2/TIMP-2 system.

Molecular Weight	394.53
Formula	C19H19KN2O3S
CAS No.	1266523-09-4

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Pioglitazone potassium 1266523-09-4 inhibitor inhibit

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