Anti-RIPK2 Polyclonal Antibody

Name: Anti-RIPK2 Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-01621
Rating: 4.5 (1 reviews)

(Synonyms: Tyrosine-protein kinase RIPK2, RIP-like-interacting CLARP kinase, RIPK2, RIP2, RICK, Receptor-interacting serine/threonine-protein kinase 2, Receptor-interacting protein 2 (RIP-2), CARDIAK, CARD-containing interleukin-1 beta-converting enzyme-associated kinase (CARD-containing IL-1 beta ICE-kinase)) Copy Product Info

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Synonyms: Tyrosine-protein kinase RIPK2, RIP-like-interacting CLARP kinase, RIPK2, RIP2, RICK, Receptor-interacting serine/threonine-protein kinase 2, Receptor-interacting protein 2 (RIP-2), CARDIAK, CARD-containing interleukin-1 beta-converting enzyme-associated kinase (CARD-containing IL-1 beta ICE-kinase)

Catalog No. TMAB-01621 Copy Product Info

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Anti-RIPK2 Polyclonal Antibody is a Rabbit antibody targeting RIPK2. Anti-RIPK2 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB.

Anti-RIPK2 Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$220	7-10 days	7-10 days
100 μL	$373	7-10 days	7-10 days
200 μL	$529	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-RIPK2 Polyclonal Antibody is a Rabbit antibody targeting RIPK2. Anti-RIPK2 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P,WB.
Synonyms	Tyrosine-protein kinase RIPK2, RIP-like-interacting CLARP kinase, RIPK2, RIP2, RICK, Receptor-interacting serine/threonine-protein kinase 2, Receptor-interacting protein 2 (RIP-2), CARDIAK, CARD-containing interleukin-1 beta-converting enzyme-associated kinase (CARD-containing IL-1 beta ICE-kinase)
Ig Type	IgG
Reactivity	Human,Mouse (predicted:Rat,Dog,Pig,Cow,Rabbit,GuineaPig)

Application	FCM IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 2ug/Test
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Cytoplasm.
Tissue Specificity	Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008].

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human RIP2
Antigen Species	Human
Gene Name	RIPK2
Gene ID	8767
Protein Name	Receptor-interacting serine/threonine-protein kinase 2
Uniprot ID	O43353
Function	Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.