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Nrf2-ARE/hMAO-B/QR2 modulator 1
🥰Excellent
Catalog No. T60395Cas No. 3035124-25-2
Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2（quinone reductase-2，NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model.
Nrf2-ARE/hMAO-B/QR2 modulator 1
🥰Excellent
Purity: 98.5%
Catalog No. T60395Cas No. 3035124-25-2
Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2（quinone reductase-2，NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $36 | In Stock | |
| 5 mg | $85 | In Stock | |
| 10 mg | $147 | In Stock | |
| 25 mg | $296 | In Stock | |
| 50 mg | $478 | In Stock | |
| 100 mg | $826 | In Stock | |
| 200 mg | $1,090 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $91 | In Stock |
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Purity:98.5%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2（quinone reductase-2，NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model. |
| In vitro | After incubating the ARE-blaHepG2 cell line with Nrf2-ARE/hMAO-B/QR2 modulator 1 for 16 hours, CCF4-AM substrate mixture was added, and fluorescence intensity was measured to assess the activity of the Nrf2-ARE pathway. The Results showed that at a concentration of 10μM, the expression of TuJ-1 and MAP-2 was highest, and the migration distance of mouse neural stem cells was also the greatest. The study indicates that Nrf2-ARE/hMAO-B/QR2 modulator 1 effectively activates the Nrf2-ARE pathway, inhibits hMAO-B and QR2, and demonstrates significant neuroprotective effects[1]. |
| Molecular Weight | 256.26 |
| Formula | C14H12N2O3 |
| Cas No. | 3035124-25-2 |
| Smiles | COC1=CC=C(/C=C/C2=NN(CC#C)C(O2)=O)C=C1 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (195.11 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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