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Nrf2-ARE/hMAO-B/QR2 modulator 1

🥰Excellent
Catalog No. T60395Cas No. 3035124-25-2

Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2（quinone reductase-2，NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model.

Nrf2-ARE/hMAO-B/QR2 modulator 1

Nrf2-ARE/hMAO-B/QR2 modulator 1

🥰Excellent
Purity: 98.5%
Catalog No. T60395Cas No. 3035124-25-2
Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2（quinone reductase-2，NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$35-In Stock
5 mg$81-In Stock
10 mg$139-In Stock
25 mg$289-In Stock
50 mg$455-In Stock
100 mg$787-In Stock
1 mL x 10 mM (in DMSO)$89-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.5%
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Product Introduction

Bioactivity
Description
Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2（quinone reductase-2，NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model.
In vitro
After incubating the ARE-blaHepG2 cell line with Nrf2-ARE/hMAO-B/QR2 modulator 1 for 16 hours, CCF4-AM substrate mixture was added, and fluorescence intensity was measured to assess the activity of the Nrf2-ARE pathway. The Results showed that at a concentration of 10μM, the expression of TuJ-1 and MAP-2 was highest, and the migration distance of mouse neural stem cells was also the greatest. The study indicates that Nrf2-ARE/hMAO-B/QR2 modulator 1 effectively activates the Nrf2-ARE pathway, inhibits hMAO-B and QR2, and demonstrates significant neuroprotective effects[1].
Chemical Properties
Molecular Weight256.26
FormulaC14H12N2O3
Cas No.3035124-25-2
SmilesCOC1=CC=C(/C=C/C2=NN(CC#C)C(O2)=O)C=C1
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (195.11 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2.5 mg/mL (9.76 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.9023 mL19.5114 mL39.0229 mL195.1143 mL
5 mM0.7805 mL3.9023 mL7.8046 mL39.0229 mL
10 mM0.3902 mL1.9511 mL3.9023 mL19.5114 mL
20 mM0.1951 mL0.9756 mL1.9511 mL9.7557 mL
50 mM0.0780 mL0.3902 mL0.7805 mL3.9023 mL
100 mM0.0390 mL0.1951 mL0.3902 mL1.9511 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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