Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

Nrf2-ARE/hMAO-B/QR2 modulator 1

Copy Product Info
😃Good
Catalog No. T60395Cas No. 3035124-25-2

Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2（quinone reductase-2，NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model.

Nrf2-ARE/hMAO-B/QR2 modulator 1

Nrf2-ARE/hMAO-B/QR2 modulator 1

Copy Product Info
😃Good
Purity: 98.5%
Catalog No. T60395Cas No. 3035124-25-2
Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2（quinone reductase-2，NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$35-In Stock
5 mg$81-In Stock
10 mg$139-In Stock
25 mg$289-In Stock
50 mg$455-In Stock
100 mg$787-In Stock
1 mL x 10 mM (in DMSO)$89-In Stock
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:98.5%
Appearance:Solid
Color:White
Contact us for more batch information

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity
Description
Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2（quinone reductase-2，NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model.
In vitro
After incubating the ARE-blaHepG2 cell line with Nrf2-ARE/hMAO-B/QR2 modulator 1 for 16 hours, CCF4-AM substrate mixture was added, and fluorescence intensity was measured to assess the activity of the Nrf2-ARE pathway. The Results showed that at a concentration of 10μM, the expression of TuJ-1 and MAP-2 was highest, and the migration distance of mouse neural stem cells was also the greatest. The study indicates that Nrf2-ARE/hMAO-B/QR2 modulator 1 effectively activates the Nrf2-ARE pathway, inhibits hMAO-B and QR2, and demonstrates significant neuroprotective effects[1].
Chemical Properties
Molecular Weight256.26
FormulaC14H12N2O3
Cas No.3035124-25-2
SmilesCOC1=CC=C(/C=C/C2=NN(CC#C)C(O2)=O)C=C1
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (195.11 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+90% Corn Oil: 2.5 mg/mL (9.76 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.9023 mL19.5114 mL39.0229 mL195.1143 mL
5 mM0.7805 mL3.9023 mL7.8046 mL39.0229 mL
10 mM0.3902 mL1.9511 mL3.9023 mL19.5114 mL
20 mM0.1951 mL0.9756 mL1.9511 mL9.7557 mL
50 mM0.0780 mL0.3902 mL0.7805 mL3.9023 mL
100 mM0.0390 mL0.1951 mL0.3902 mL1.9511 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy Nrf2-ARE/hMAO-B/QR2 modulator 1 | purchase Nrf2-ARE/hMAO-B/QR2 modulator 1 | Nrf2-ARE/hMAO-B/QR2 modulator 1 cost | order Nrf2-ARE/hMAO-B/QR2 modulator 1 | Nrf2-ARE/hMAO-B/QR2 modulator 1 chemical structure | Nrf2-ARE/hMAO-B/QR2 modulator 1 in vitro | Nrf2-ARE/hMAO-B/QR2 modulator 1 formula | Nrf2-ARE/hMAO-B/QR2 modulator 1 molecular weight
TargetMol | Logo

Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.