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Anti-ICOS ligand Antibody-APC (1W488)
🥰Excellent
Catalog No. TMAY-01901A
Anti-ICOS ligand Antibody-APC (1W488) is a APC-conjugated Mouse antibody targeting ICOS ligand. Anti-ICOS ligand Antibody-APC (1W488) can be used in FCM.
Anti-ICOS ligand Antibody-APC (1W488)
Anti-ICOS ligand Antibody-APC (1W488)
🥰Excellent
Catalog No. TMAY-01901A
Anti-ICOS ligand Antibody-APC (1W488) is a APC-conjugated Mouse antibody targeting ICOS ligand. Anti-ICOS ligand Antibody-APC (1W488) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-ICOS ligand Antibody-APC (1W488) is a APC-conjugated Mouse antibody targeting ICOS ligand. Anti-ICOS ligand Antibody-APC (1W488) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 1W488 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of ICOSLG(CD275) expression on RPMI8226 cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ICOS Ligand / B7-H2 (rh ICOS Ligand / B7-H2; TMPY-01672; NP_056074.1; Met1-Ser258) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| Conjucates | APC |
| Others Formats | Unconjugated/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human ICOS Ligand / B7-H2 protein (TMPY-01672) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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