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Pipecuronium bromide

Name: Pipecuronium bromide
Brand: TargetMol
SKU: T12481
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12481Cas No. 52212-02-9

Alias RGH-1106

Pipecuronium bromide (RGH-1106) is a selective and potent nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker, causing muscle relaxation, often in conjunction with antibiotics.

Pipecuronium bromide

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Catalog No. T12481Alias RGH-1106Cas No. 52212-02-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$106	In Stock	In Stock
25 mg	$213	In Stock	In Stock
50 mg	$347	In Stock	In Stock
100 mg	$553	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pipecuronium bromide (RGH-1106) is a selective and potent nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker, causing muscle relaxation, often in conjunction with antibiotics.
In vitro	Sugammadex exhibits a high affinity for Pipecuronium bromide, which is 6 to 7 times more potent than Rocuronium, thereby enabling a more effective molecular blockade compared to Rocuronium [3].
In vivo	Sugammadex adequately and rapidly reverses pipecuronium bromide induced moderate NMB during sevoflurane anesthesia. Once the train-of-four count has spontaneously returned to 2 responses following pipecuronium bromide administration, a dose of 2.0 mg/kg of sugammadex is sufficient to reverse the NMB[2].Carboxymethylated γ-cyclodextrin demonstrates efficient and complete reversal of the Pipecuronium bromide-induced neuromuscular block in an ex vivo rat diaphragm experiment [1].
Synonyms	RGH-1106

Chemical Properties

Molecular Weight	762.7
Formula	C₃₅H₆₂Br₂N₄O₄
Cas No.	52212-02-9
Smiles	C[C@@]12[C@](C[C@H](N3CC[N+](C)(CC3)C)[C@@H]2OC(C)=O)([H])[C@@]4([H])[C@@](CC1)([H])[C@@]5([C@@](C[C@@H]([C@@H](N6CC[N+](C)(CC6)C)C5)OC(C)=O)([H])CC4)C.[Br-].[Br-]
Relative Density.	1.329

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (104.89 mM), Sonication is recommended.

DMSO: 120 mg/mL (157.34 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3111 mL	6.5557 mL	13.1113 mL	65.5566 mL
5 mM	0.2622 mL	1.3111 mL	2.6223 mL	13.1113 mL
10 mM	0.1311 mL	0.6556 mL	1.3111 mL	6.5557 mL
20 mM	0.0656 mL	0.3278 mL	0.6556 mL	3.2778 mL
50 mM	0.0262 mL	0.1311 mL	0.2622 mL	1.3111 mL
100 mM	0.0131 mL	0.0656 mL	0.1311 mL	0.6556 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc