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Anti-Phospho-PLCG1 (Tyr775) Polyclonal Antibody
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Catalog No. TMAB-11172
Anti-Phospho-PLCG1 (Tyr775) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PLCG1 (Tyr775). Anti-Phospho-PLCG1 (Tyr775) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-PLCG1 (Tyr775) Polyclonal Antibody
Anti-Phospho-PLCG1 (Tyr775) Polyclonal Antibody
😃Good
Catalog No. TMAB-11172
Anti-Phospho-PLCG1 (Tyr775) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PLCG1 (Tyr775). Anti-Phospho-PLCG1 (Tyr775) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-PLCG1 (Tyr775) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PLCG1 (Tyr775). Anti-Phospho-PLCG1 (Tyr775) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Dog,Cow,Horse) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human PLC gamma 1 around the phosphorylation site of Tyr775 |
| Antigen Species | Human |
| Gene Name | PLCG1 |
| Gene ID | |
| Protein Name | 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-1 |
| Uniprot ID | |
| Function | Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. |
| Molecular Weight | Theoretical: 148 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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