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Mal-NH-PEG2-CH2CH2COOPFP ester

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Catalog No. T18257Cas No. 1347750-81-5

Mal-NH-PEG2-CH2CH2COOPFP ester, a polyethylene glycol (PEG) derived linker, is specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Mal-NH-PEG2-CH2CH2COOPFP ester

Mal-NH-PEG2-CH2CH2COOPFP ester

😃Good
Catalog No. T18257Cas No. 1347750-81-5
Mal-NH-PEG2-CH2CH2COOPFP ester, a polyethylene glycol (PEG) derived linker, is specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
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Product Introduction

Bioactivity
Description
Mal-NH-PEG2-CH2CH2COOPFP ester, a polyethylene glycol (PEG) derived linker, is specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
In vitro
PROTACs consist of two distinct ligands connected by a linker: one binds to an E3 ubiquitin ligase, and the other to the target protein. They utilize the intracellular ubiquitin-proteasome system to achieve selective degradation of target proteins [1].
Chemical Properties
Molecular Weight494.37
FormulaC20H19F5N2O7
Cas No.1347750-81-5
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Keywords

PEGsMal-NH-PEG2-CH2CH2COOPFP esterMal-NH-PEG-2-CH2CH2COOPFP esterMalNHPEG2CH2CH2COOPFP esterMal NH PEG2 CH2CH2COOPFP ester
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