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PD-1/PD-L1-IN-43

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Catalog No. T209760

PD-1/PD-L1-IN-43 (Compound Z13) is a small molecule inhibitor that specifically targets the interaction between PD-1 and PD-L1. It exhibits significant in vivo antitumor activity against B16-F10 melanoma. By disrupting the interaction between PD-1 and PD-L1, PD-1/PD-L1-IN-43 effectively inhibits tumor growth and is applicable in antitumor research.

PD-1/PD-L1-IN-43

PD-1/PD-L1-IN-43

😃Good
Catalog No. T209760
PD-1/PD-L1-IN-43 (Compound Z13) is a small molecule inhibitor that specifically targets the interaction between PD-1 and PD-L1. It exhibits significant in vivo antitumor activity against B16-F10 melanoma. By disrupting the interaction between PD-1 and PD-L1, PD-1/PD-L1-IN-43 effectively inhibits tumor growth and is applicable in antitumor research.
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
PD-1/PD-L1-IN-43 (Compound Z13) is a small molecule inhibitor that specifically targets the interaction between PD-1 and PD-L1. It exhibits significant in vivo antitumor activity against B16-F10 melanoma. By disrupting the interaction between PD-1 and PD-L1, PD-1/PD-L1-IN-43 effectively inhibits tumor growth and is applicable in antitumor research.
In vitro
PD-1/PD-L1-IN-43 (0 - 20 μM; 48 h) activates immunosuppressed Jurkat T cells, enabling them to kill HepG2 cells in a co-culture system.
In vivo
PD-1/PD-L1-IN-43 (administered at 20 and 40 mg/kg via intraperitoneal injection, once daily for 2 weeks) effectively inhibits tumor growth in male C57BL/6J mice by activating the tumor immune microenvironment.
Chemical Properties
FormulaC27H25N3O4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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