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Dupilumab
🥰Excellent
Catalog No. T13666Cas No. 1190264-60-8
Alias SAR-231893, REGN-668
Dupilumab (REGN-668) is a fully human monoclonal antibody targeting the alpha subunit of the interleukin-4 receptor, thereby inhibiting IL-4 and IL-13 signaling. As a systemic immunomodulator, it has demonstrated efficacy in improving atopic dermatitis.
Dupilumab
🥰Excellent
Purity: 98%
Catalog No. T13666Alias SAR-231893, REGN-668Cas No. 1190264-60-8
Dupilumab (REGN-668) is a fully human monoclonal antibody targeting the alpha subunit of the interleukin-4 receptor, thereby inhibiting IL-4 and IL-13 signaling. As a systemic immunomodulator, it has demonstrated efficacy in improving atopic dermatitis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $239 | In Stock | In Stock | |
| 5 mg | $589 | In Stock | In Stock | |
| 10 mg | $858 | - | In Stock | |
| 25 mg | $1,280 | - | In Stock | |
| 50 mg | $1,750 | - | In Stock | |
| 100 mg | $2,370 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Dupilumab (REGN-668) is a fully human monoclonal antibody targeting the alpha subunit of the interleukin-4 receptor, thereby inhibiting IL-4 and IL-13 signaling. As a systemic immunomodulator, it has demonstrated efficacy in improving atopic dermatitis. |
| Targets&IC50 | IL-4Rα (dimeric):12 pM (KD), IL-4Rα (monomeric):33 pM (KD) |
| In vitro | Dupilumab inhibited mRNA expression of T cells, dc, eosinophils, inflammatory pathways and Th2-induced chemokine activation related genes in skin lesions, and showed no activity against IL-17A and significantly decreased IL-22 levels, but 300 mg Dupilumab significantly decreased the expression of IL-17-related genes. Such as elafin (PI3), IL23p19/IL23A and S100A8, and have inhibitory potential (CXCL1 and S100A7). Dupilumab (300 mg) inhibited hyperproliferation-related genes, such as K16, and decreased the expression of S100A, as measured by microarray and qRT-PCR.[1] |
| In vivo | In human whole blood, dupilumab inhibits IL-4 and il-13 to stimulate thymus secretion and activates chemokine/chemokine C motif ligand 17 (TARC/CCL17). (Clinical biomarker for atopic dermatitis) with yarnamore potency (50% inhibition at 0.24 to 0.52 nM and 0.26 to 0.27 nM).[1] |
| Synonyms | SAR-231893, REGN-668 |
| Cas No. | 1190264-60-8 |
| Relative Density. | no data available |
| Color | White |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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