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7 Beta-Hydroxycholesterol

Name: 7 Beta-Hydroxycholesterol
Brand: TargetMol
SKU: TN1338
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1338Cas No. 566-27-8

Alias 7β-Hydroxycholesterol

7 Beta-Hydroxycholesterol (7β-Hydroxycholesterol) is an oxysterol contained in animal-derived foods. It is an oxidative stress inducer and a candidate marker for assessing cardiovascular risk factors in obesity. It can induce oxidative stress and inflammation and promote atherosclerosis.

7 Beta-Hydroxycholesterol

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Purity: 99.24%

Catalog No. TN1338Alias 7β-HydroxycholesterolCas No. 566-27-8

Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$147	In Stock
10 mg	$239	In Stock

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Batch Information

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Purity:99.24%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	7 Beta-Hydroxycholesterol (7β-Hydroxycholesterol) is an oxysterol contained in animal-derived foods. It is an oxidative stress inducer and a candidate marker for assessing cardiovascular risk factors in obesity. It can induce oxidative stress and inflammation and promote atherosclerosis.
In vitro	b>METHODS: Human NCI-H460 lung cancer cells were treated with 7β-Hydroxycholesterol (10, 20 and 30 μM for 14 days) and subjected to a clonogenic survival assay. RESULTS: 7β-Hydroxycholesterol inhibited the clonogenic survival of NCI-H460 cells in a dose-dependent manner, with survival rates of 102%, 75%, 35% and 12% at concentrations of 5, 10, 20 and 30 μM, respectively. [1]
Synonyms	7β-Hydroxycholesterol

Chemical Properties

Molecular Weight	402.65
Formula	C₂₇H₄₆O₂
Cas No.	566-27-8
Smiles	C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=C[C@@H]3O)C[C@@H](O)CC4)(CC1)[H])[H])(CC[C@@]2([C@@H](CCCC(C)C)C)[H])[H]
Relative Density.	1.03 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (198.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.2 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4835 mL	12.4177 mL	24.8355 mL	124.1773 mL
5 mM	0.4967 mL	2.4835 mL	4.9671 mL	24.8355 mL
10 mM	0.2484 mL	1.2418 mL	2.4835 mL	12.4177 mL
20 mM	0.1242 mL	0.6209 mL	1.2418 mL	6.2089 mL
50 mM	0.0497 mL	0.2484 mL	0.4967 mL	2.4835 mL
100 mM	0.0248 mL	0.1242 mL	0.2484 mL	1.2418 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc