Shopping Cart

Your shopping cart is currently empty

Atazanavir

Name: Atazanavir
Brand: TargetMol
SKU: T0100L
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Zrivada, Reyataz, Latazanavir, BMS-232632) Copy Product Info

😃Good

Synonyms: Zrivada, Reyataz, Latazanavir, BMS-232632

Catalog No. T0100L Copy Product Info

Purity: 99.95%

😃Good

Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.

Cas No. 198904-31-3

Pack Size	Price	USA Stock	Global Stock
5 mg	$39	In Stock	In Stock
10 mg	$56	In Stock	In Stock
25 mg	$87	In Stock	In Stock
50 mg	$123	In Stock	In Stock
100 mg	$189	In Stock	In Stock
500 mg	$473	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$63	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.95%

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.
In vitro	Atazanavir has potent in vitro activity with 50 and 90% effective concentrations(EC50) of 2-5 nM and 9-15 nM respectively against wild type virus[1]. Atazanavir is able to potently induce endoplasmic reticulum (ER) stress response in malignant glioma cells, as indicated by elevated levels of GRP78 and CHOP, and activation of caspase-4, which leads to cell death[3].
In vivo	Atazanavir has excellent oral bioavailability in the range of 60-70%[1].
Synonyms	Zrivada, Reyataz, Latazanavir, BMS-232632
Kinase Assay	Protease assays: To determine the inhibition constants (Ki) for each Prt inhibitor, purified HIV-1 RF wild-type Prt (2.5 nM) is incubated at 37 ℃ with 1 μM to 15 μM fluorogenic substrate in reaction buffer (1 M NaCl, 1 mM EDTA, 0.1 M sodium acetate [pH 5.5], 0.1% polyethylene glycol 8000) in the presence or absence of Atazanavir. Cleavage of the substrate is quantified by measuring an increase in fluorescent emission at 490 nM after excitation at 340 nM using a Cytofluor 4000. Reactions are carried out using 1.36 μM, 1.66 μM, 2.1 μM, 3.0 μM, 5.0 μM, or 15 μM substrate in the presence of five concentrations of Atazanavir (1.25 nM to 25 nM). Substrate cleavage is monitored at 5-min intervals for 30 min. Cleavage rates are then determined for each sample at early time points in the reaction, and Ki values are determined from the slopes of the resulting Michaelis-Menten plots.
Cell Research	U251, T98 g, and LN229 glioblastoma cell lines are exposed to increasing concentrations of nelfinavir and atazanavir. Cells cultured in 96-well plates are treated with drugs for 48 h, and cell growth and survival are determined by conventional MTT assay.(Only for Reference)

Chemical Properties

Molecular Weight	704.86
Formula	C₃₈H₅₂N₆O₇
Cas No.	198904-31-3
Smiles	N(CC1=CC=C(C=C1)C2=CC=CC=N2)(C[C@@H]([C@H](CC3=CC=CC=C3)NC([C@@H](NC(OC)=O)[C@@](C)(C)C)=O)O)NC([C@@H](NC(OC)=O)[C@](C)(C)C)=O
Relative Density.	1.178 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 32 mg/mL (45.4 mM), Sonication is recommended.

DMSO: 250 mg/mL (354.68 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Saline: < 10 mg/mL (14.19 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: < 10 mg/mL (14.19 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+90% (20% SBE-β-CD in Saline): < 10 mg/mL (14.19 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+90% Corn oil: 10 mg/mL (14.19 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4187 mL	7.0936 mL	14.1872 mL	70.9361 mL
5 mM	0.2837 mL	1.4187 mL	2.8374 mL	14.1872 mL
10 mM	0.1419 mL	0.7094 mL	1.4187 mL	7.0936 mL
20 mM	0.0709 mL	0.3547 mL	0.7094 mL	3.5468 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0284 mL	0.1419 mL	0.2837 mL	1.4187 mL
100 mM	0.0142 mL	0.0709 mL	0.1419 mL	0.7094 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Related Tags: Atazanavir chemical structure | Atazanavir in vivo | Atazanavir in vitro | Atazanavir formula | Atazanavir molecular weight