Shopping Cart

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Taltobulin

Copy Product Info

🥰Excellent

Catalog No. TQ0141Cas No. 228266-40-8

Alias SPA-110, HTI-286

Taltobulin (HTI-286) is a synthetic analog of the tripeptide cysteine, a microtubule protein inhibitor that inhibits liver tumor cell proliferation in vitro and tumor growth in vivo.Taltobulin is cytotoxic, induces mitotic arrest and apoptosis, and may be used in the study of breast cancer and microtubule tissue-related diseases.

Taltobulin

Copy Product Info

🥰Excellent

Purity: 99.86%

Catalog No. TQ0141Alias SPA-110, HTI-286Cas No. 228266-40-8

Product information is being updated, if you want to purchase, please click the bulk custom button.

Add to Quotation

Questions

Batch Information

Select Batch

Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Taltobulin (HTI-286) is a synthetic analog of the tripeptide cysteine, a microtubule protein inhibitor that inhibits liver tumor cell proliferation in vitro and tumor growth in vivo.Taltobulin is cytotoxic, induces mitotic arrest and apoptosis, and may be used in the study of breast cancer and microtubule tissue-related diseases.
In vitro	In leukemia CCRF-CEM cell line, ovarian 1A9 cell line, non-small cell lung cancer A549 cell line, and NCI-H1299 cell line, Taltobulin (0.2-7.3 nM; 3 days) inhibited the growth of tumor cell lines with IC50 values of 0.2±0.03 nM, 0.6±0.1 nM, 1.1±0.5 nM, and 6.8±6.1 nM, respectively[1].
In vivo	In athymic nu/nu female mice with Lox melanoma model (5-6 weeks of age), treatment with Taltobulin (1.6 mg/kg; administered i.v.; for 35 days) resulted in a 96-98% inhibition of Lox tumor growth on day 12 compared to the control group[1].
Synonyms	SPA-110, HTI-286

Chemical Properties

Molecular Weight	473.65
Formula	C₂₇H₄₃N₃O₄
Cas No.	228266-40-8
Smiles	CN[C@H](C(=O)N[C@H](C(=O)N(C)[C@H](\C=C(/C)C(O)=O)C(C)C)C(C)(C)C)C(C)(C)c1ccccc1
Relative Density.	1.063 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (168.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1113 mL	10.5563 mL	21.1126 mL	105.5632 mL
5 mM	0.4223 mL	2.1113 mL	4.2225 mL	21.1126 mL
10 mM	0.2111 mL	1.0556 mL	2.1113 mL	10.5563 mL
20 mM	0.1056 mL	0.5278 mL	1.0556 mL	5.2782 mL
50 mM	0.0422 mL	0.2111 mL	0.4223 mL	2.1113 mL
100 mM	0.0211 mL	0.1056 mL	0.2111 mL	1.0556 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc