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Taltobulin

Name: Taltobulin
Brand: TargetMol
SKU: TQ0141
Rating: 4.5 (1 reviews)

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Catalog No. TQ0141Cas No. 228266-40-8

Alias SPA-110, HTI-286

Taltobulin (HTI-286) is a synthetic analog of the tripeptide cysteine, a microtubule protein inhibitor that inhibits liver tumor cell proliferation in vitro and tumor growth in vivo.Taltobulin is cytotoxic, induces mitotic arrest and apoptosis, and may be used in the study of breast cancer and microtubule tissue-related diseases.

Taltobulin

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Purity: 99.86%

Catalog No. TQ0141Alias SPA-110, HTI-286Cas No. 228266-40-8

Product information is being updated, if you want to purchase, please click the bulk custom button.

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Batch Information

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Purity:99.86%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Taltobulin (HTI-286) is a synthetic analog of the tripeptide cysteine, a microtubule protein inhibitor that inhibits liver tumor cell proliferation in vitro and tumor growth in vivo.Taltobulin is cytotoxic, induces mitotic arrest and apoptosis, and may be used in the study of breast cancer and microtubule tissue-related diseases.
In vitro	In leukemia CCRF-CEM cell line, ovarian 1A9 cell line, non-small cell lung cancer A549 cell line, and NCI-H1299 cell line, Taltobulin (0.2-7.3 nM; 3 days) inhibited the growth of tumor cell lines with IC50 values of 0.2±0.03 nM, 0.6±0.1 nM, 1.1±0.5 nM, and 6.8±6.1 nM, respectively[1].
In vivo	In athymic nu/nu female mice with Lox melanoma model (5-6 weeks of age), treatment with Taltobulin (1.6 mg/kg; administered i.v.; for 35 days) resulted in a 96-98% inhibition of Lox tumor growth on day 12 compared to the control group[1].
Synonyms	SPA-110, HTI-286

Chemical Properties

Molecular Weight	473.65
Formula	C₂₇H₄₃N₃O₄
Cas No.	228266-40-8
Smiles	CN[C@H](C(=O)N[C@H](C(=O)N(C)[C@H](\C=C(/C)C(O)=O)C(C)C)C(C)(C)C)C(C)(C)c1ccccc1
Relative Density.	1.063 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (168.90 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1113 mL	10.5563 mL	21.1126 mL	105.5632 mL
5 mM	0.4223 mL	2.1113 mL	4.2225 mL	21.1126 mL
10 mM	0.2111 mL	1.0556 mL	2.1113 mL	10.5563 mL
20 mM	0.1056 mL	0.5278 mL	1.0556 mL	5.2782 mL
50 mM	0.0422 mL	0.2111 mL	0.4223 mL	2.1113 mL
100 mM	0.0211 mL	0.1056 mL	0.2111 mL	1.0556 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc