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LH17
Catalog No. T214808 Copy Product Info
🥰Excellent
LH17 is a derivative of Kaempferol and serves as a potent and selective inhibitor of PDE4, with PDE4D2 IC50 at 73 nM and PDE4B2 IC50 at 190 nM. It demonstrates over 136-fold selectivity against other PDE isoenzymes (PDE1B/2A/3A/5A/8A/9A/10A) with IC50s greater than 10000 nM, except for PDE7A1 which has an IC50 of 300 nM. LH17 exhibits unique interactions with the M pocket of PDE4. In vitro and in vivo models show that LH17 has significant antifibrotic effects. This compound is applicable in the study of idiopathic pulmonary fibrosis (IPF).
LH17
Copy Product Info🥰Excellent
Catalog No. T214808
LH17 is a derivative of Kaempferol and serves as a potent and selective inhibitor of PDE4, with PDE4D2 IC50 at 73 nM and PDE4B2 IC50 at 190 nM. It demonstrates over 136-fold selectivity against other PDE isoenzymes (PDE1B/2A/3A/5A/8A/9A/10A) with IC50s greater than 10000 nM, except for PDE7A1 which has an IC50 of 300 nM. LH17 exhibits unique interactions with the M pocket of PDE4. In vitro and in vivo models show that LH17 has significant antifibrotic effects. This compound is applicable in the study of idiopathic pulmonary fibrosis (IPF).
LH17
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | LH17 is a derivative of Kaempferol and serves as a potent and selective inhibitor of PDE4, with PDE4D2 IC50 at 73 nM and PDE4B2 IC50 at 190 nM. It demonstrates over 136-fold selectivity against other PDE isoenzymes (PDE1B/2A/3A/5A/8A/9A/10A) with IC50s greater than 10000 nM, except for PDE7A1 which has an IC50 of 300 nM. LH17 exhibits unique interactions with the M pocket of PDE4. In vitro and in vivo models show that LH17 has significant antifibrotic effects. This compound is applicable in the study of idiopathic pulmonary fibrosis (IPF). |
| Targets&IC50 | PDE4D2:73 nM |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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