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SB-334867 free base

Name: SB-334867 free base
Brand: TargetMol
SKU: T6140
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6140Cas No. 792173-99-0

Alias SB334867A free base, SB-334867, SB334867, SB 334867

SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist. In CHO-OX1 cells, SB-334867 inhibits calcium responses mediated by the human OX1 receptor in a concentration-dependent manner, with a binding pKi value of 7.17 for the human OX1 receptor.

SB-334867 free base

🥰Excellent

Purity: 99.69%

Catalog No. T6140Alias SB334867A free base, SB-334867, SB334867, SB 334867Cas No. 792173-99-0

Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$64	In Stock
10 mg	$100	In Stock
25 mg	$163	In Stock
50 mg	$238	In Stock
100 mg	$355	In Stock
200 mg	$528	In Stock
1 mL x 10 mM (in DMSO)	$71	In Stock

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Purity:99.69%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist. In CHO-OX1 cells, SB-334867 inhibits calcium responses mediated by the human OX1 receptor in a concentration-dependent manner, with a binding pKi value of 7.17 for the human OX1 receptor.
Targets&IC50	OXB:100 nM, OX1:40 nM, OXA:10 nM
In vitro	In CHO-OX1 cells, SB-334867 inhibits the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses with pKB of 7.27 and 7.23 respectively, without effect on the UTP (3 microM)-induced calcium response. [1]
In vivo	In both male and female rats, SB-334867 (30 mg/kg, i.p.) significantly reduces natural and orexin-A-induced food intake. [2] SB-334867 (2 mg/kg, i.v.) blocks the effects of antipsychotic drugs on dopamine neuronal activity in rats. [3]
Synonyms	SB334867A free base, SB-334867, SB334867, SB 334867

Chemical Properties

Molecular Weight	319.32
Formula	C₁₇H₁₃N₅O₂
Cas No.	792173-99-0
Smiles	N(C(NC=1C=C2C(=CC1)N=C(C)O2)=O)C=3C4=C(N=CC3)C=CC=N4
Relative Density.	1.472 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 3.2 mg/mL (10 mM)), Heating is recommended.

DMSO: 31.9 mg/mL (100 mM), Heating is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1317 mL	15.6583 mL	31.3165 mL	156.5827 mL
5 mM	0.6263 mL	3.1317 mL	6.2633 mL	31.3165 mL
10 mM	0.3132 mL	1.5658 mL	3.1317 mL	15.6583 mL

DMSO

	1mg	5mg	10mg	50mg
20 mM	0.1566 mL	0.7829 mL	1.5658 mL	7.8291 mL
50 mM	0.0626 mL	0.3132 mL	0.6263 mL	3.1317 mL
100 mM	0.0313 mL	0.1566 mL	0.3132 mL	1.5658 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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