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Revusiran
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Catalog No. T38918Cas No. 1438322-82-7
Alias ALN-TTRSC
Revusiran (ALN-TTRSC) is a first-generation short interfering RNA (siRNA) that specifically targets transthyretin (TTR) mRNA and is utilized in TTR-mediated amyloidosis research.
Revusiran
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Catalog No. T38918Alias ALN-TTRSCCas No. 1438322-82-7
Revusiran (ALN-TTRSC) is a first-generation short interfering RNA (siRNA) that specifically targets transthyretin (TTR) mRNA and is utilized in TTR-mediated amyloidosis research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Revusiran (ALN-TTRSC) is a first-generation short interfering RNA (siRNA) that specifically targets transthyretin (TTR) mRNA and is utilized in TTR-mediated amyloidosis research. |
| In vitro | Revusiran is a first-generation, chemically synthesized, double-stranded short interfering RNA (siRNA) with its sense strand's 3′-end covalently bonded to a triantennary GalNAc (N-acetylgalactosamine) ligand. This design enables Revusiran to specifically target transthyretin (TTR) mRNA, facilitating its delivery to hepatocytes. The uptake occurs through the asialoglycoprotein receptors, optimizing the compound's efficiency in silencing the TTR gene[1]. |
| In vivo | In monkeys, single doses up to 100 mg/kg do not affect cardiovascular or respiratory functions, and no neurological effects were observed in repeat-dose studies up to 300 mg/kg. Similarly, revusiran demonstrates good tolerability in mice (weekly doses) and both rats and monkeys (five daily doses followed by weekly doses) in toxicity studies[1]. |
| Synonyms | ALN-TTRSC |
| Cas No. | 1438322-82-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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