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Benzquinamide
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Catalog No. T12343Cas No. 63-12-7
Alias P2647, BZQ, Benzoquinamide
Benzquinamide (P2647), an antiemetic agent with anticancer activity, inhibits p-glycoprotein-mediated drug efflux and potentiates the cytotoxicity of anticancer drugs in multidrug-resistant cells.The Ki values of Benzquinamide for α2A, α2B, and α2C adrenergic receptor (α2-AR) were 1,365, 691, and 545 nM, respectively. 545 nM, respectively.
Benzquinamide
Copy Product Info😃Good
Catalog No. T12343Alias P2647, BZQ, BenzoquinamideCas No. 63-12-7
Benzquinamide (P2647), an antiemetic agent with anticancer activity, inhibits p-glycoprotein-mediated drug efflux and potentiates the cytotoxicity of anticancer drugs in multidrug-resistant cells.The Ki values of Benzquinamide for α2A, α2B, and α2C adrenergic receptor (α2-AR) were 1,365, 691, and 545 nM, respectively. 545 nM, respectively.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $195 | - | In Stock | |
| 5 mg | $483 | 3-6 months | 3-6 months |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Appearance:Solid
Color:Yellow
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Product Introduction
Benzquinamide AI Summary
Benzquinamide demonstrates a wide range of bioactivities and potential therapeutic applications. It shows antiviral activity by blocking the entry of the Ebola virus, with AC50 values ranging from 1778.3 nM to 17782.8 nM across different assays. In addition, it exhibits antiviral activity against SARS-CoV-2 by inhibiting cytotoxicity in VERO-6 cells with moderate to high potency, as indicated by its IC50 values. The compound also shows varied binding affinities to multiple receptors and channels in both human and rat systems, including significant interactions with receptors such as DRD2, ADRA2B, ADRA2A, and HTR2B, with AC50 values in the lower nanomolar range. Incucyte cell viability assays reveal moderate to high effects on HEK293T cells and a broader range of bioactivity, including potential cytotoxic effects on human fibroblast cells. Furthermore, the compound affects protein thermal stability, showing variable impacts on melting temperatures across different protein domains. These diverse bioactivities suggest that Benzquinamide holds promise for further investigation in antiviral and other therapeutic contexts..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Benzquinamide (P2647), an antiemetic agent with anticancer activity, inhibits p-glycoprotein-mediated drug efflux and potentiates the cytotoxicity of anticancer drugs in multidrug-resistant cells.The Ki values of Benzquinamide for α2A, α2B, and α2C adrenergic receptor (α2-AR) were 1,365, 691, and 545 nM, respectively. 545 nM, respectively. |
| Targets&IC50 | α2A-adrenoceptor:1,365 nM (Ki), α2B-adrenoceptor:691 nM (Ki), α2C-adrenoceptor:545 nM (Ki) |
| Synonyms | P2647, BZQ, Benzoquinamide |
| Molecular Weight | 404.5 |
| Formula | C22H32N2O5 |
| Cas No. | 63-12-7 |
| Smiles | CCN(CC)C(=O)C1CN2CCc3cc(OC)c(OC)cc3C2CC1OC(C)=O |
| Relative Density. | 1.19 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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