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NBI-31772

Name: NBI-31772
Brand: TargetMol
SKU: T8906
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8906Cas No. 374620-70-9

Alias NBI31772, NBI 31772

NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM). NBI-31772 can be used in research on IGF-responsive diseases.

NBI-31772

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Purity: 99.79%

Catalog No. T8906Alias NBI31772, NBI 31772Cas No. 374620-70-9

NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM). NBI-31772 can be used in research on IGF-responsive diseases.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$122	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$347	In Stock	In Stock
50 mg	$553	In Stock	In Stock
100 mg	$793	-	In Stock
1 mL x 10 mM (in DMSO)	$142	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.79%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

NBI-31772 AI Summary

NBI-31772 exhibits inhibitory activity against various Insulin-like Growth Factor Binding Proteins (IGFBPs) including IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4, and IGFBP-5 with Ki values ranging from 1.04 nM to 5.6 nM. It also shows a binding affinity for IGFBP-6 with a Ki value of 23.65 nM. The compound has the ability to displace Insulin-Like Growth Factor I (IGF-I) from its binding to human IGFBP-3 and IGFBP-5 with Ki values of 5.6 nM, and has a calculated partition coefficient (clogP) value of 1.7. These properties suggest that NBI-31772 may have potential bioactivity in modulating IGF-I interactions with several IGFBPs..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM). NBI-31772 can be used in research on IGF-responsive diseases.
Synonyms	NBI31772, NBI 31772

Chemical Properties

Molecular Weight	341.27
Formula	C₁₇H₁₁NO₇
Cas No.	374620-70-9
Smiles	OC(=O)c1cc2cc(O)c(O)cc2c(n1)C(=O)c1ccc(O)c(O)c1
Relative Density.	1.696 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (439.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9302 mL	14.6512 mL	29.3023 mL	146.5116 mL
5 mM	0.5860 mL	2.9302 mL	5.8605 mL	29.3023 mL
10 mM	0.2930 mL	1.4651 mL	2.9302 mL	14.6512 mL
20 mM	0.1465 mL	0.7326 mL	1.4651 mL	7.3256 mL
50 mM	0.0586 mL	0.2930 mL	0.5860 mL	2.9302 mL
100 mM	0.0293 mL	0.1465 mL	0.2930 mL	1.4651 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc