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Anti-CK2 alpha/CSNK2A1 Antibody (2J938)
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Catalog No. TMAH-00306
Alias CSNK2A3, CKII, CK2A1, CK2 α/CSNK2A1, casein kinase 2, α1 polypeptide, casein kinase 2, alpha 1 polypeptide
Anti-CK2 alpha/CSNK2A1 Antibody (2J938) is an antibody targeting CK2 alpha/CSNK2A1. Anti-CK2 alpha/CSNK2A1 Antibody (2J938) can be used in ELISA, WB.
Anti-CK2 alpha/CSNK2A1 Antibody (2J938)
Anti-CK2 alpha/CSNK2A1 Antibody (2J938)
😃Good
Catalog No. TMAH-00306Alias CSNK2A3, CKII, CK2A1, CK2 α/CSNK2A1, casein kinase 2, α1 polypeptide, casein kinase 2, alpha 1 polypeptide
Anti-CK2 alpha/CSNK2A1 Antibody (2J938) is an antibody targeting CK2 alpha/CSNK2A1. Anti-CK2 alpha/CSNK2A1 Antibody (2J938) can be used in ELISA, WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $208 | 7-10 days | |
| 100 μL | $347 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Monoclonal Application: ELISA, WB Reactivity: Human, Mouse |
| Alias | CSNK2A3, CKII, CK2A1, CK2 α/CSNK2A1, casein kinase 2, α1 polypeptide, casein kinase 2, alpha 1 polypeptide |
| Ig Type | Rabbit IgG |
| Clone | 2J938 |
| Reactivity | Human, Mouse |
| Verified Activity | Western Blot -Positive WB detected in: NIH/3T3 whole cell lysate, 293 whole cell lysate, Jurkat whole cell lysate, Hela whole cell lysate, A549 whole cell lysate, U-87 whole cell lysate -All lanes: CKII alpha antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 46, 30 kDa -Observed band size: 45 kDa |
| Application | ELISA, WB |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Nucleus. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, ATF4, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Mediates sequential phosphorylation of FNIP1, promoting its gradual interaction with Hsp90, leading to activate both kinase and non-kinase client proteins of Hsp90. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry. Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human CKII alpha |
| Antigen Species | Human |
| Gene ID | 1457 |
| Uniprot ID | |
| Biology Area | Cell biology, Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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