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BTK IN-1

Name: BTK IN-1
Brand: TargetMol
SKU: TQ0230
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0230Cas No. 1270014-40-8

Alias SNS062 analog

BTK IN-1 [SNS062 analog] is an effective BTK inhibitor with an IC50 of less than 100 nM.

BTK IN-1

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Purity: 97.38%

Catalog No. TQ0230Alias SNS062 analogCas No. 1270014-40-8

BTK IN-1 [SNS062 analog] is an effective BTK inhibitor with an IC50 of less than 100 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
2 mg	$45	In Stock	In Stock
5 mg	$73	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$189	In Stock	In Stock
50 mg	$328	In Stock	In Stock
100 mg	$463	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.38%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

BTK IN-1 AI Summary

BTK IN-1 exhibits notable antiviral activity against the SARS-CoV-2 (USA-WA1/2020 strain), with a hit score of 0.1071, as determined by imaging in HRCE cells at MOI 0.4 after 96 hours. Additionally, the compound demonstrates significant bioactivity as an inhibitor of Bruton's tyrosine kinase (BTK), with IC50 values reported as 80.0 nM and 190.0 nM in a FRET assay after a 30-minute incubation period, and as low as 1.9 nM in other assays, indicating its potent reversible inhibition of BTK..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BTK IN-1 [SNS062 analog] is an effective BTK inhibitor with an IC50 of less than 100 nM.
Targets&IC50	BTK:<100 nM
Synonyms	SNS062 analog

Chemical Properties

Molecular Weight	384.86
Formula	C₁₉H₂₁ClN₆O
Cas No.	1270014-40-8
Smiles	Clc1cccc(NCC(=O)NC2CCCN(C2)c2ncnc3[nH]ccc23)c1
Relative Density.	1.40 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 95 mg/mL (246.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.5 mg/mL (6.5 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5983 mL	12.9917 mL	25.9835 mL	129.9174 mL
5 mM	0.5197 mL	2.5983 mL	5.1967 mL	25.9835 mL
10 mM	0.2598 mL	1.2992 mL	2.5983 mL	12.9917 mL
20 mM	0.1299 mL	0.6496 mL	1.2992 mL	6.4959 mL
50 mM	0.0520 mL	0.2598 mL	0.5197 mL	2.5983 mL
100 mM	0.0260 mL	0.1299 mL	0.2598 mL	1.2992 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc