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IDOR-1117-2520
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Catalog No. T86705Cas No. 2737274-49-4
IDOR-1117-2520 is a potent and selective CCR6 antagonist that effectively blocks CCL20-mediated calcium signaling and inhibits β-arrestin recruitment in human CCR6-expressing cells, thereby serving as a valuable pharmacological agent for investigating CCR6-driven immune cell migration and autoimmune disease mechanisms.
IDOR-1117-2520
Copy Product Info😃Good
Catalog No. T86705Cas No. 2737274-49-4
IDOR-1117-2520 is a potent and selective CCR6 antagonist that effectively blocks CCL20-mediated calcium signaling and inhibits β-arrestin recruitment in human CCR6-expressing cells, thereby serving as a valuable pharmacological agent for investigating CCR6-driven immune cell migration and autoimmune disease mechanisms.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $2,570 | 10-14 weeks | 10-14 weeks | |
| 50 mg | $3,360 | 10-14 weeks | 10-14 weeks | |
| 100 mg | $4,210 | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Chemical Properties
Storage & Solubility Information
| Description | IDOR-1117-2520 is a potent and selective CCR6 antagonist that effectively blocks CCL20-mediated calcium signaling and inhibits β-arrestin recruitment in human CCR6-expressing cells, thereby serving as a valuable pharmacological agent for investigating CCR6-driven immune cell migration and autoimmune disease mechanisms. |
| In vivo | In the context of autoimmune disease models, IDOR-1117-2520 is evaluated for its ability to mitigate tissue inflammation. By preventing the infiltration of pathogenic Th17 cells into inflamed tissues, the compound aims to dampen the autoimmune response and reduce pathology. This mechanism is investigated in preclinical models of autoimmunity, such as skin inflammation (psoriasis) or intestinal inflammation (IBD) [1]. |
| Molecular Weight | 436.55 |
| Formula | C25H32N4O3 |
| Cas No. | 2737274-49-4 |
| Smiles | [C@](O)(C1(C)CN(C)C1)(C=2C=C(C=NC2)C=3N=C(C(C)(C)O)ON3)C4=CC=C(C(C)C)C=C4 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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