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Nicotiflorin

Name: Nicotiflorin
Brand: TargetMol
SKU: T6S1294
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S1294Cas No. 17650-84-9

Alias Nictoflorin, Nicotifloroside, Kaempferol-3-O-Rutinoside

1. Nicotiflorin (Kaempferol-3-O-Rutinoside) has potential therapeutic effects on cerebral ischemic illness. 2. Nicotiflorin has protective effects on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats.

Nicotiflorin

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Purity: 99.96%

Catalog No. T6S1294Alias Nictoflorin, Nicotifloroside, Kaempferol-3-O-RutinosideCas No. 17650-84-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
5 mg	$84	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$196	In Stock	In Stock
50 mg	$298	In Stock	In Stock
100 mg	$442	In Stock	In Stock
200 mg	$643	-	In Stock
1 mL x 10 mM (in DMSO)	$109	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.96%

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Nicotiflorin AI Summary

Nicotiflorin demonstrates multifaceted bioactivity across various biological assays. It inhibits the diphenolase activity of mushroom tyrosinase at 0.056 mM, resulting in 16.05% inhibition, and further inhibits tyrosinase activity with an IC50 of 0.908 µg/mL. It shows antiprotozoal effects against Entamoeba histolytica and Giardia lamblia with IC50 values of 30.9 µg/mL and 22.5 µg/mL, respectively. This compound also acts as a ligand for the adenosine A1 receptor, displacing 37.0% of bound ligand at 100 µg/mL in rat forebrain membrane studies. Moreover, Nicotiflorin reduces uric acid production by inhibiting xanthine oxidase (IC50 of 14800 nM) and displays antioxidant activities, including superoxide-scavenging (IC50 of 3400 nM) and DPPH radical scavenging, though with a high IC50 of over 100,000 nM in certain assays. It affects the complement system by inhibiting the classical pathway by 19.2% at 1000 µM and activating the alternative pathway by 18.4% at the same concentration. Antiviral properties of Nicotiflorin show efficacy against influenza A H9N2 and H1N1 strains, with EC50 values of 72,900 nM and 40,100 nM, respectively. It noncompetitively inhibits neuraminidase with Ki and IC50 values around 32,700 nM and 31,700 nM. Despite cytotoxicity against MDCK cells, it has a selectivity index greater than 7.48 for H1N1 and 4.12 for H9N2, indicating selective antiviral activity. In enzymatic assays, Nicotiflorin inhibits various targets, including AmpC Beta-Lactamase (562.3 nM), Bacillus stearothermophilus alpha-glucosidase (IC50 of 109,900 nM), and Sprague-Dawley rat lens aldose reductase (IC50 of 11,300 nM). It also exhibits inhibitory effects against human and mouse cell lines impacting inflammatory signaling, namely TNF-alpha-induced NF-kappaB activation in HEK293 cells (62% inhibition at 50 µM) and cytokine production in mouse BMDCs with IC50 values greater than 50,000 nM. Lastly, Nicotiflorin shows anti-inflammatory and antineuroinflammatory activities by inhibiting NO production and TNF-alpha secretion in various cell types, including mouse RAW264.7 and BV2 cells, with respective IC50 values of 45,300 nM and 41,500 nM. Its cytotoxicity varies across different human and animal cell lines, demonstrating specific neuroprotective activity in rat C6 cells and a notable anti-austerity activity against nutrient-deprived human PANC1 cells (PC50 of 67.1 µM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Nicotiflorin (Kaempferol-3-O-Rutinoside) has potential therapeutic effects on cerebral ischemic illness. 2. Nicotiflorin has protective effects on reducing memory dysfunction, energy metabolism failure and oxidative stress in multi-infarct dementia model rats.
Synonyms	Nictoflorin, Nicotifloroside, Kaempferol-3-O-Rutinoside

Chemical Properties

Molecular Weight	594.52
Formula	C₂₇H₃₀O₁₅
Cas No.	17650-84-9
Smiles	C[C@@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3c(oc4cc(O)cc(O)c4c3=O)-c3ccc(O)cc3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O
Relative Density.	1.76g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: Soluble

Pyridine, Methanol, etc.: Soluble

DMSO: 260 mg/mL (437.33 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6820 mL	8.4101 mL	16.8203 mL	84.1015 mL
5 mM	0.3364 mL	1.6820 mL	3.3641 mL	16.8203 mL
10 mM	0.1682 mL	0.8410 mL	1.6820 mL	8.4101 mL
20 mM	0.0841 mL	0.4205 mL	0.8410 mL	4.2051 mL
50 mM	0.0336 mL	0.1682 mL	0.3364 mL	1.6820 mL
100 mM	0.0168 mL	0.0841 mL	0.1682 mL	0.8410 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc