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D8-MMAD

Name: D8-MMAD
Brand: TargetMol
SKU: T10947
Rating: 4.5 (1 reviews)

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Catalog No. T10947

Alias Monomethylauristatin D D8, Monomethyl Dolastatin 10 D8, Demethyldolastatin 10 D8

D8-MMAD is a deuterated form of MMAD, which is a microtubule destroyer.

D8-MMAD

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Catalog No. T10947Alias Monomethylauristatin D D8, Monomethyl Dolastatin 10 D8, Demethyldolastatin 10 D8

D8-MMAD is a deuterated form of MMAD, which is a microtubule destroyer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$971	Inquiry	Inquiry
5 mg	$2,202	Inquiry	Inquiry
10 mg	$4,136	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry
100 mg	Inquiry	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$3,546	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	D8-MMAD is a deuterated form of MMAD, which is a microtubule destroyer.
In vitro	MMAD (monomethyl Dolastatin 10) is coupled through a stable oxime ligation process to produce several nearly uniform antibody-drug conjugates (ADC) with a pharmacodynamic ratio of approximately 2.0. The resulting conjugate showed good pharmacokinetic properties and had strong in vitro cytotoxic activity against HER2 + cancer cells. Compared with ADCs prepared by cysteine alkylation after reduction of natural interchain disulfide bonds, site-based unnatural amino acid-based ADCs have higher cytotoxicity in vitro.
In vivo	The resulting antibody-drug conjugate (ADC) showed complete tumor regression in rodents. Their toxicological characteristics in rats have also been improved.
Synonyms	Monomethylauristatin D D8, Monomethyl Dolastatin 10 D8, Demethyldolastatin 10 D8

Chemical Properties

Molecular Weight	779.11
Formula	C₄₁H₅₈D₈N₆O₆S
Smiles	O=C(N[C@H](C1=NC=CS1)CC2=CC=CC=C2)[C@H](C)[C@@H](OC)[C@H]3N(C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@](C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])([2H])NC([C@H](C(C)C)NC)=O)=O)C)=O)CCC3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (128.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2835 mL	6.4176 mL	12.8352 mL	64.1758 mL
5 mM	0.2567 mL	1.2835 mL	2.5670 mL	12.8352 mL
10 mM	0.1284 mL	0.6418 mL	1.2835 mL	6.4176 mL
20 mM	0.0642 mL	0.3209 mL	0.6418 mL	3.2088 mL
50 mM	0.0257 mL	0.1284 mL	0.2567 mL	1.2835 mL
100 mM	0.0128 mL	0.0642 mL	0.1284 mL	0.6418 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

D8-MMADD-8-MMADD8MMADD8 MMAD