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Tizaterkib

Name: Tizaterkib
Brand: TargetMol
SKU: T10429
Price: 96 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10429Cas No. 2097416-76-5

Alias AZD-0364

Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.

Tizaterkib

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Purity: 99.63%

Catalog No. T10429Alias AZD-0364Cas No. 2097416-76-5

Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$96	In Stock	In Stock
2 mg	$139	In Stock	In Stock
5 mg	$231	In Stock	In Stock
10 mg	$368	In Stock	In Stock
25 mg	$653	In Stock	In Stock
50 mg	$937	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$242	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.63%

Appearance:Solid

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.
Targets&IC50	ERK2:0.6 nM
In vitro	AZD-0364 is measured in the ERK2 mass spectrometry and A375 phospho-p90RSK assays (IC50s: 0.6 nM and 5.7 nM). AZD-0364 can inhibit the growth of a panel of cancer cell lines (A549, H2122, H2009, and Calu6 cell lines) with KRAS mutations as monotherapy.
In vivo	In the A549 xenograft model, Selumetinib is dosed twice daily (BiD) 8 hours apart and AZD-0364 ethanesulfonic acid is dosed once daily (QD) 4 hours after the first Selumetinib dose. Both compounds are dosed continuously for 3 weeks. Both vehicles are dosed in the vehicle group. Both Selumetinib and AZD-0364 ethanesulfonic acid reduce tumor growth relative to vehicle-only control. The combination of Selumetinib and AZD-0364 ethanesulfonic acid results in a reduction in tumor growth.
Synonyms	AZD-0364

Chemical Properties

Molecular Weight	494.5
Formula	C₂₄H₂₄F₂N₈O₂
Cas No.	2097416-76-5
Smiles	COC[C@H]1Cn2cc(nc2C(=O)N1Cc1ccc(F)c(F)c1)-c1nc(Nc2ccnn2C)ncc1C
Relative Density.	1.45 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (202.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0222 mL	10.1112 mL	20.2224 mL	101.1122 mL
5 mM	0.4044 mL	2.0222 mL	4.0445 mL	20.2224 mL
10 mM	0.2022 mL	1.0111 mL	2.0222 mL	10.1112 mL
20 mM	0.1011 mL	0.5056 mL	1.0111 mL	5.0556 mL
50 mM	0.0404 mL	0.2022 mL	0.4044 mL	2.0222 mL
100 mM	0.0202 mL	0.1011 mL	0.2022 mL	1.0111 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc