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Tramiprosate
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Catalog No. T0883Cas No. 3687-18-1
Alias Homotaurine, Alzhemed, 3-Amino-1-propanesulfonic acid
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GABA analog with neuroprotective, anticonvulsant, and antihypertensive activity.
Tramiprosate
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Purity: 99%
Catalog No. T0883Alias Homotaurine, Alzhemed, 3-Amino-1-propanesulfonic acidCas No. 3687-18-1
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GABA analog with neuroprotective, anticonvulsant, and antihypertensive activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 500 mg | $42 | - | In Stock | |
| 1 g | $50 | - | In Stock | |
| 5 g | $94 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99%
Appearance:Solid
Color:White
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Product Introduction
Tramiprosate AI Summary
Tramiprosate demonstrates a multifaceted bioactivity profile, including the inhibition of Gamma-aminobutyric acid type B receptor sites (IC50 of 2000 nM) and affinity for the Gamma-aminobutyric acid A receptor (IC50 of 300 nM) in rat brain membranes. It shows significant potency in various assays: as an inhibitor of T. brucei phosphofructokinase (12.0 nM), Mammalian Selenoprotein Thioredoxin Reductase 1 (13371.4 nM), Histone Lysine Methyltransferase G9a (39810.7 nM), and Human Apurinic/apyrimidinic Endonuclease 1 (50118.7 nM). Additionally, it inhibits amyloid beta (1–42) aggregation (IC50 of 100000 nM) and displays antivirus activity against SARS-CoV-2 by reducing cytotoxicity in Caco-2 and VERO-6 cells. It also inhibits SARS-CoV-2 3CL-Pro protease with notable inhibition rates and inhibits human HDAC6 enzyme activity. However, it exhibits toxicity in Sprague-Dawley rats and shows potential cognitive-enhancing effects in mice. Its proline uptake inhibition in human Caco2 cells is significant (Ki value of 7100000 nM). Tramiprosate has a half-life greater than 9 hours when administered daily in humans, presenting various therapeutic potentials despite its associated toxic effects at higher doses..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GABA analog with neuroprotective, anticonvulsant, and antihypertensive activity. |
| Synonyms | Homotaurine, Alzhemed, 3-Amino-1-propanesulfonic acid |
| Molecular Weight | 139.17 |
| Formula | C3H9NO3S |
| Cas No. | 3687-18-1 |
| Smiles | NCCCS(O)(=O)=O |
| Relative Density. | 1.387 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Slightly soluble  |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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