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CSRM617 hydrochloride

Name: CSRM617 hydrochloride
Brand: TargetMol
SKU: T10896L
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10896LCas No. 1353749-74-2

Alias CSRM617 hydrochloride(787504-88-5 Free base)

CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 µM in SPR assays, directly binding to the OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP and is well tolerated in the mouse model of prostate cancer [1].

CSRM617 hydrochloride

🥰Excellent

Purity: 99.59%

Catalog No. T10896LAlias CSRM617 hydrochloride(787504-88-5 Free base)Cas No. 1353749-74-2

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$52	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$156	In Stock	In Stock
50 mg	$230	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.59%

Appearance:Solid

Color:White

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COA LCMS IC HNMR

Product Introduction

Bioactivity

Description	CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 µM in SPR assays, directly binding to the OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP and is well tolerated in the mouse model of prostate cancer [1].
In vitro	CSRM617 hydrochloride, within a concentration range of 0.01-100 μM applied over 48 hours, effectively inhibits the growth of various prostate cancer (PC) cell lines, including PC-3, 22RV1, LNCaP, and C4-2 cells. Furthermore, at concentrations of 10-20 μM over the same duration, it triggers concentration-dependent apoptosis in 22Rv1 cells, evidenced by cell death. Notably, a higher concentration of 20 μM administered for 72 hours leads to apoptosis in 22Rv1 cells, marked by the presence of cleaved Caspase-3 and PARP.
In vivo	CSRM617, administered orally at a dosage of 50 mg/kg daily for 20 days, significantly inhibits tumor growth in SCID mice with 22Rv1 xenografts. This regimen was observed to notably impede the development and proliferation of diffuse metastases in the tested animal model.
Synonyms	CSRM617 hydrochloride(787504-88-5 Free base)

Chemical Properties

Molecular Weight	291.69
Formula	C₁₀H₁₄ClN₃O₅
Cas No.	1353749-74-2
Smiles	Cl.NC(CO)C(=O)N\N=C\c1ccc(O)c(O)c1O
Relative Density.	1.68 g/cm3 at 21℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (154.27 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (6.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4283 mL	17.1415 mL	34.2830 mL	171.4149 mL
5 mM	0.6857 mL	3.4283 mL	6.8566 mL	34.2830 mL
10 mM	0.3428 mL	1.7141 mL	3.4283 mL	17.1415 mL
20 mM	0.1714 mL	0.8571 mL	1.7141 mL	8.5707 mL
50 mM	0.0686 mL	0.3428 mL	0.6857 mL	3.4283 mL
100 mM	0.0343 mL	0.1714 mL	0.3428 mL	1.7141 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc