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Anti-SCIN Antibody (8Z929)

😃Good
Catalog No. TMAB-12577

Anti-SCIN Antibody (8Z929) is a Rabbit antibody targeting SCIN. Anti-SCIN Antibody (8Z929) can be used in WB.

Anti-SCIN Antibody (8Z929)

Anti-SCIN Antibody (8Z929)

😃Good
Catalog No. TMAB-12577
Anti-SCIN Antibody (8Z929) is a Rabbit antibody targeting SCIN. Anti-SCIN Antibody (8Z929) can be used in WB.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1487-10 days7-10 days
50 μL$2637-10 days7-10 days
100 μL$4717-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-SCIN Antibody (8Z929) is a Rabbit antibody targeting SCIN. Anti-SCIN Antibody (8Z929) can be used in WB.
Ig Type
IgG
Clone
8Z929
Reactivity
Mouse,Rat (predicted:Human)
Application
Recommended Dose
WB=1:500-2000
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasmic, cytoskeleton.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundCa2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane.Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate.In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles.
Antigen Details
Immunogen
A synthesized peptide: human Scinderin
Antigen Species
Human
Gene Name
SCIN
Gene ID
Protein Name
Scinderin
Uniprot ID
Function
Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity).
Chemical Properties
Molecular WeightTheoretical: 80 kDa. Actual: 80 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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