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NSCLC-IN-1
🥰Excellent
Catalog No. T209735
NSCLC-IN-1 (Compound A10-2) targets transmembrane BAX inhibitor motif containing 6 (TMBIM6) to induce mitophagy and ferroptosis. It causes mitochondrial Ca2+ imbalance, resulting in mitochondrial damage. Additionally, NSCLC-IN-1 reduces intracellular glutathione (GSH) levels while increasing the accumulation of lipid peroxides (LPO) and malondialdehyde (MDA). NSCLC-IN-1 is a potent anti-NSCLC compound.
NSCLC-IN-1
NSCLC-IN-1
🥰Excellent
Catalog No. T209735
NSCLC-IN-1 (Compound A10-2) targets transmembrane BAX inhibitor motif containing 6 (TMBIM6) to induce mitophagy and ferroptosis. It causes mitochondrial Ca2+ imbalance, resulting in mitochondrial damage. Additionally, NSCLC-IN-1 reduces intracellular glutathione (GSH) levels while increasing the accumulation of lipid peroxides (LPO) and malondialdehyde (MDA). NSCLC-IN-1 is a potent anti-NSCLC compound.
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Bioactivity
Chemical Properties
| Description | NSCLC-IN-1 (Compound A10-2) targets transmembrane BAX inhibitor motif containing 6 (TMBIM6) to induce mitophagy and ferroptosis. It causes mitochondrial Ca2+ imbalance, resulting in mitochondrial damage. Additionally, NSCLC-IN-1 reduces intracellular glutathione (GSH) levels while increasing the accumulation of lipid peroxides (LPO) and malondialdehyde (MDA). NSCLC-IN-1 is a potent anti-NSCLC compound. |
| Formula | C46H56N2O13 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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