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Ac-muramic acid
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Catalog No. T38317Cas No. 10597-89-4
Alias NAMA, N-Acetylmuramic aci, MurNAc
Ac-muramic acid (MurNAc) is an essential component of bacterial peptidoglycan, the structural polymer of the cell wall. Ac-muramic acid is covalently linked to N-acetylglucosamine through β-1,4 linkages and may also be connected via the hydroxyl group on carbon-4 to the carbon atom of L-alanine, forming part of the peptide stem. MurNAc is central to bacterial cell wall biosynthesis studies.
Ac-muramic acid
😃Good
Purity: 99.97%
Catalog No. T38317Alias NAMA, N-Acetylmuramic aci, MurNAcCas No. 10597-89-4
Ac-muramic acid (MurNAc) is an essential component of bacterial peptidoglycan, the structural polymer of the cell wall. Ac-muramic acid is covalently linked to N-acetylglucosamine through β-1,4 linkages and may also be connected via the hydroxyl group on carbon-4 to the carbon atom of L-alanine, forming part of the peptide stem. MurNAc is central to bacterial cell wall biosynthesis studies.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 5 mg | $94 | In Stock | |
| 10 mg | $138 | In Stock | |
| 50 mg | $411 | 35 days |
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Purity:99.97%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ac-muramic acid (MurNAc) is an essential component of bacterial peptidoglycan, the structural polymer of the cell wall. Ac-muramic acid is covalently linked to N-acetylglucosamine through β-1,4 linkages and may also be connected via the hydroxyl group on carbon-4 to the carbon atom of L-alanine, forming part of the peptide stem. MurNAc is central to bacterial cell wall biosynthesis studies. |
| In vitro | Methods: RAW264.7 cells were treated with Ac-muramic acid (100-300 μg/mL, 48 hours), and the expression of related proteins was analyzed by Western Blot. Results: Ac-muramic acid inhibited the expression of iNOS and COX-2 proteins. [1] |
| In vivo | Method: Ac-muramic acid (10-40 mg/kg, once daily for 28 consecutive days) was orally administered to E. coli-infected mouse models to investigate the anti-inflammatory effects of N-Acetylmuramic acid. Results: Ac-muramic acid inhibited intestinal villus edema and thickening in mice and increased the level of secretory immunoglobulin A (sIgA) in the intestinal tract of mice.[1] |
| Synonyms | NAMA, N-Acetylmuramic aci, MurNAc |
| Molecular Weight | 293.27 |
| Formula | C11H19NO8 |
| Cas No. | 10597-89-4 |
| Smiles | C[C@@H](O[C@@H]([C@H](O)[C@H](O)CO)[C@@H](NC(C)=O)C=O)C(O)=O |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMF: 2.5 mg/mL (8.52 mM), Sonication is recommended. H2O: 80 mg/mL (272.79 mM), Sonication is recommended. PBS (pH 7.2): 10 mg/mL (34.1 mM), Sonication is recommended. DMSO: 30 mg/mL (102.29 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||||||||||||
DMF/PBS (pH 7.2)/DMSO/H2O
PBS (pH 7.2)/DMSO/H2O
DMSO/H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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