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Ac-muramic acid

Name: Ac-muramic acid
Brand: TargetMol
SKU: T38317
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38317Cas No. 10597-89-4

Alias NAMA, N-Acetylmuramic aci, MurNAc

Ac-muramic acid (MurNAc) is an essential component of bacterial peptidoglycan, the structural polymer of the cell wall. Ac-muramic acid is covalently linked to N-acetylglucosamine through β-1,4 linkages and may also be connected via the hydroxyl group on carbon-4 to the carbon atom of L-alanine, forming part of the peptide stem. MurNAc is central to bacterial cell wall biosynthesis studies.

Ac-muramic acid

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Purity: 99.97%

Catalog No. T38317Alias NAMA, N-Acetylmuramic aci, MurNAcCas No. 10597-89-4

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$29	-	In Stock
5 mg	$49	-	In Stock
10 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	Ac-muramic acid (MurNAc) is an essential component of bacterial peptidoglycan, the structural polymer of the cell wall. Ac-muramic acid is covalently linked to N-acetylglucosamine through β-1,4 linkages and may also be connected via the hydroxyl group on carbon-4 to the carbon atom of L-alanine, forming part of the peptide stem. MurNAc is central to bacterial cell wall biosynthesis studies.
In vitro	Methods: RAW264.7 cells were treated with Ac-muramic acid (100-300 μg/mL, 48 hours), and the expression of related proteins was analyzed by Western Blot. Results: Ac-muramic acid inhibited the expression of iNOS and COX-2 proteins. [1]
In vivo	Method: Ac-muramic acid (10-40 mg/kg, once daily for 28 consecutive days) was orally administered to E. coli-infected mouse models to investigate the anti-inflammatory effects of N-Acetylmuramic acid. Results: Ac-muramic acid inhibited intestinal villus edema and thickening in mice and increased the level of secretory immunoglobulin A (sIgA) in the intestinal tract of mice.[1]
Synonyms	NAMA, N-Acetylmuramic aci, MurNAc

Chemical Properties

Molecular Weight	293.27
Formula	C₁₁H₁₉NO₈
Cas No.	10597-89-4
Smiles	C[C@@H](O[C@@H]([C@H](O)[C@H](O)CO)[C@@H](NC(C)=O)C=O)C(O)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 2.5 mg/mL (8.52 mM), Sonication is recommended.

H2O: 80 mg/mL (272.79 mM), Sonication is recommended.

PBS (pH 7.2): 10 mg/mL (34.1 mM), Sonication is recommended.

DMSO: 30 mg/mL (102.29 mM), Sonication is recommended.

Solution Preparation Table

DMF/PBS (pH 7.2)/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.4098 mL	17.0491 mL	34.0983 mL	170.4914 mL
5 mM	0.6820 mL	3.4098 mL	6.8197 mL	34.0983 mL

PBS (pH 7.2)/DMSO/H2O

	1mg	5mg	10mg	50mg
10 mM	0.3410 mL	1.7049 mL	3.4098 mL	17.0491 mL
20 mM	0.1705 mL	0.8525 mL	1.7049 mL	8.5246 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
50 mM	0.0682 mL	0.3410 mL	0.6820 mL	3.4098 mL
100 mM	0.0341 mL	0.1705 mL	0.3410 mL	1.7049 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc