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AGN 194310

Name: AGN 194310
Brand: TargetMol
SKU: T14143
Rating: 4.5 (1 reviews)

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Catalog No. T14143Cas No. 229961-45-9

Alias VTP-194310

AGN 194310 (VTP-194310) is a pan-antagonist for retinoic acid receptors (RARs), with Kd values of 3 nM, 2 nM, and 5 nM for RARα, RARβ, and RARγ, respectively[1][2].

AGN 194310

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Catalog No. T14143Alias VTP-194310Cas No. 229961-45-9

AGN 194310 (VTP-194310) is a pan-antagonist for retinoic acid receptors (RARs), with Kd values of 3 nM, 2 nM, and 5 nM for RARα, RARβ, and RARγ, respectively[1][2].

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$596	8-10 weeks	8-10 weeks
25 mg	$1,710	8-10 weeks	8-10 weeks
50 mg	$2,230	8-10 weeks	8-10 weeks
100 mg	$3,390	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	AGN 194310 (VTP-194310) is a pan-antagonist for retinoic acid receptors (RARs), with Kd values of 3 nM, 2 nM, and 5 nM for RARα, RARβ, and RARγ, respectively[1][2].
Targets&IC50	RARα:3 nM （kd）, RARγ:5 nM （kd）, RARβ:2 nM （kd）
In vitro	AGN194310 effectively inhibits colony formation in LNCaP, PC3, and DU-145 cells with IC50 values of 16 nM, 18 nM, and 34 nM, respectively[2]. At concentrations of 50 nM and 100 nM, both alone and combined with TTNPB, AGN194310 inhibits colony formation in these cell lines[2]. Additionally, treatment with AGN194310 (1 μM for 72 hours) results in 80% apoptosis in LNCaP cells[2].
In vivo	AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment significantly increases granulocyte numbers across hematopoietic compartments and the frequency of granulocyte-progenitor cells in bone marrow[3].
Synonyms	VTP-194310

Chemical Properties

Molecular Weight	424.55
Formula	C₂₈H₂₄O₂S
Cas No.	229961-45-9
Smiles	CCc1ccc(cc1)C1=CC(C)(C)Sc2ccc(cc12)C#Cc1ccc(cc1)C(O)=O
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (117.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1.67 mg/mL (3.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3554 mL	11.7772 mL	23.5544 mL	117.7718 mL
5 mM	0.4711 mL	2.3554 mL	4.7109 mL	23.5544 mL
10 mM	0.2355 mL	1.1777 mL	2.3554 mL	11.7772 mL
20 mM	0.1178 mL	0.5889 mL	1.1777 mL	5.8886 mL
50 mM	0.0471 mL	0.2355 mL	0.4711 mL	2.3554 mL
100 mM	0.0236 mL	0.1178 mL	0.2355 mL	1.1777 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc