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Dimethylenastron

Name: Dimethylenastron
Brand: TargetMol
SKU: T3118
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T3118Cas No. 863774-58-7

Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.

Dimethylenastron

🥰Excellent

Purity: 98.07%

Catalog No. T3118Cas No. 863774-58-7

Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.

Pack Size	Price	Availability
1 mg	$30	In Stock
2 mg	$40	In Stock
5 mg	$56	In Stock
10 mg	$89	In Stock
25 mg	$158	In Stock
50 mg	$247	In Stock
100 mg	$372	In Stock
1 mL x 10 mM (in DMSO)	$62	In Stock

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Batch Information

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Purity:98.07%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.
Targets&IC50	EG5:200 nM.
In vitro	Dimethylenastron (DMN) inhibits the growth of LECs and HUVECs in a dose- and time-dependent manner.

Chemical Properties

Molecular Weight	302.39
Formula	C₁₆H₁₈N₂O₂S
Cas No.	863774-58-7
Smiles	O=C1C=2C(NC(=S)NC2CC(C)(C)C1)C3=CC(O)=CC=C3
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (181.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3070 mL	16.5349 mL	33.0699 mL	165.3494 mL
5 mM	0.6614 mL	3.3070 mL	6.6140 mL	33.0699 mL
10 mM	0.3307 mL	1.6535 mL	3.3070 mL	16.5349 mL
20 mM	0.1653 mL	0.8267 mL	1.6535 mL	8.2675 mL
50 mM	0.0661 mL	0.3307 mL	0.6614 mL	3.3070 mL
100 mM	0.0331 mL	0.1653 mL	0.3307 mL	1.6535 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc