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Osteogenic Growth Peptide, OGP acetate

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Catalog No. TP1820L
Alias Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base)

Osteogenic Growth Peptide, OGP acetate is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations. Osteogenic growth peptide OGP is a key factor in the mechanism of the systemic osteogenic response to local bone marrow injury.

Osteogenic Growth Peptide, OGP acetate
Other Forms of Osteogenic Growth Peptide, OGP acetate:
Osteogenic Growth Peptide, OGPTP1820132996-61-3
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Osteogenic Growth Peptide, OGP acetate

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Purity: 97.87%
Catalog No. TP1820LAlias Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base)
Osteogenic Growth Peptide, OGP acetate is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations. Osteogenic growth peptide OGP is a key factor in the mechanism of the systemic osteogenic response to local bone marrow injury.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$115In StockIn Stock
5 mg$450In StockIn Stock
10 mg$663In StockIn Stock
25 mg$987In StockIn Stock
50 mg$1,390In StockIn Stock
100 mg$1,880In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.87%
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COA HPLC MS

Product Introduction

Bioactivity
Description
Osteogenic Growth Peptide, OGP acetate is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations. Osteogenic growth peptide OGP is a key factor in the mechanism of the systemic osteogenic response to local bone marrow injury.
In vitro
Osteogenic Growth Peptide (OGP) regulates proliferation, differentiation, and matrix mineralization in osteoblast lineage cells. The active portion of OGP, the OGP(10-14) region, is cleaved from the peptide and binds to the OGP receptor which activates the MAP kinase, the Src, and the RhoA pathways[1]. Osteogenic Growth Peptide (OGP) is a native molecule with a primary structure identical to the C-terminus of histone H4, whose sequence contains a highly conserved 14-amino acid motif (NH2-ALKRQGRTLYGFGG-OH). This peptide is isolated from blood during osteogenic remodeling of post-ablation of marrow regeneration. The osteogenic growth peptide (OGP) and its C-terminal pentapeptide OGP(10-14) have been shown to stimulate the proliferation, differentiation, alkaline phosphatase activity and matrix mineralization of osteoblastic lineage cells[2].
SynonymsOsteogenic Growth Peptide, OGP acetate(132996-61-3 free base)
Chemical Properties
Molecular Weight1583.82
FormulaC70H114N22O20
SmilesCC(O)=O.O=C(O)CNC(CNC([C@H](CC1=CC=CC=C1)NC(CNC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](C)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Relative Density.no data available
SequenceH-Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-Gly-Gly-OH
Sequence ShortALKRQGRTLYGFGG
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 5 mM, Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.6314 mL3.1569 mL6.3138 mL31.5692 mL
5 mM0.1263 mL0.6314 mL1.2628 mL6.3138 mL

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TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Osteogenic Growth Peptide, OGP Acetate
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