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WXM-1-170
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Catalog No. T209338
WXM-1-170 (compound 10) is a derivative of Indisulam that inhibits the migration of gastric cancer cells. It attenuates the PI3K/AKT/GSK-3β/β-catenin signaling pathway.
WXM-1-170
WXM-1-170
😃Good
Catalog No. T209338
WXM-1-170 (compound 10) is a derivative of Indisulam that inhibits the migration of gastric cancer cells. It attenuates the PI3K/AKT/GSK-3β/β-catenin signaling pathway.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | WXM-1-170 (compound 10) is a derivative of Indisulam that inhibits the migration of gastric cancer cells. It attenuates the PI3K/AKT/GSK-3β/β-catenin signaling pathway. |
| In vitro | WXM-1-170 inhibits AGS cell growth with an IC50 value of 24.75 μM when used at concentrations ranging from 0.0001 to 100 µM over 48 hours. Additionally, at a concentration of 10 µM for 48 to 72 hours, it exhibits anti-migratory effects in both AGS and MGC803 cells. Furthermore, WXM-1-170 at 10 µM for 48 hours upregulates E-cadherin expression and downregulates the expression of N-cadherin and vimentin in AGS and MGC803 cells. |
| Formula | C17H13ClN4O3S |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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