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WXM-1-170
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Catalog No. T209338
WXM-1-170 (compound 10) is a derivative of Indisulam that inhibits the migration of gastric cancer cells. It attenuates the PI3K/AKT/GSK-3β/β-catenin signaling pathway.
WXM-1-170
WXM-1-170
Copy Product Info😃Good
Catalog No. T209338
WXM-1-170 (compound 10) is a derivative of Indisulam that inhibits the migration of gastric cancer cells. It attenuates the PI3K/AKT/GSK-3β/β-catenin signaling pathway.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | WXM-1-170 (compound 10) is a derivative of Indisulam that inhibits the migration of gastric cancer cells. It attenuates the PI3K/AKT/GSK-3β/β-catenin signaling pathway. |
| In vitro | WXM-1-170 inhibits AGS cell growth with an IC50 value of 24.75 μM when used at concentrations ranging from 0.0001 to 100 µM over 48 hours. Additionally, at a concentration of 10 µM for 48 to 72 hours, it exhibits anti-migratory effects in both AGS and MGC803 cells. Furthermore, WXM-1-170 at 10 µM for 48 hours upregulates E-cadherin expression and downregulates the expression of N-cadherin and vimentin in AGS and MGC803 cells. |
| Formula | C17H13ClN4O3S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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